Parallel Fluorescence Correlation Spectroscopy with a fully integrated single photon 2 x 2 detector array made with conventional CMOS technology

机译：具有完全集成的单光子2 x 2检测器阵列的平行荧光相关光谱法，该阵列采用常规CMOS技术制成

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We present multipoint Fluorescence Correlation Spectroscopy (FCS) experiments with a fully integrated Complementary Metal Oxide Semiconductor (CMOS) single photon 2x2 detector array. Multifocal excitation was achieved with a diffractive optical element (DOE). Special emphasis was put on parallelization of the total system. In particular the performance of the single-photon CMOS detector was investigated and compared to a state-of-the art single-photon detecting module (actively quenched avalanche photo diode) by measurements on free diffusing molecules at different concentrations. The potential of our new technique for high throughput FCS based systems is discussed.

机译：我们目前使用完全集成的互补金属氧化物半导体（CMOS）单光子2x2检测器阵列进行多点荧光相关光谱（FCS）实验。用衍射光学元件（DOE）实现了多焦点激发。特别强调了整个系统的并行化。特别地，通过对不同浓度的自由扩散分子进行测量，研究了单光子CMOS检测器的性能，并将其与最新的单光子检测模块（有源淬火雪崩光电二极管）进行了比较。讨论了我们的新技术在基于FCS的高吞吐量系统中的潜力。

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来源
《Conference on Optical Technologies in Biophysics and Medicine V and Saratov Fall Meeting; 20031007-20031010; Saratov; RU》|2003年|P.248-258|共11页
会议地点 Saratov(RU);Saratov(RU);Saratov(RU)
作者
Alexandre Serov; Michael Goesch; Alexis Rochas; Hans Blom; Tiemo Anhut; Pierre-Andre Besse; Radivoje S. Popovic; Theo Lasser; Rudolf Rigler;
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作者单位

Institute for Biomedical Imaging, Optics and Engineering of the Swiss Federal Institute of Technology, CH-1015, Lausanne, Switzerland;

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原文格式 PDF
正文语种 eng
中图分类生物医学工程;
关键词
fluorescent correlation spectroscopy; single-molecule detection; single-photon detector; CMOS technology; diffractive optics;

机译：荧光相关光谱法；单分子检测；单光子检测器； CMOS技术；衍射光学;

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专利

1. First fully integrated 2-D array of single-photon detectors in standard CMOS technology [J] . Rochas A., Gosch M., Serov A., IEEE Photonics Technology Letters . 2003,第7期

机译：采用标准CMOS技术的首个完全集成的二维单光子探测器二维阵列
2. High concentration factor diffractive microlenses integrated with CMOS single-photon avalanche diode detector arrays for fill-factor improvement [J] . Applied optics . 2020,第14期

机译：高浓度因子衍射微透镜与CMOS单光子雪崩二极管探测器阵列集成，用于填充因子改善
3. Fully Integrated Single Photon Avalanche Diode Detector in Standard CMOS 0.18- $mu$m Technology [J] . Faramarzpour N., Deen M. J., Shirani S., IEEE Transactions on Electron Devices . 2008,第3期

机译：采用标准CMOS0.18-μM技术的全集成单光子雪崩二极管检测器
4. Parallel Fluorescence Correlation Spectroscopy with a fully integrated single photon 2 x 2 detector array made with conventional CMOS technology [C] . Alexandre Serov, Michael Goesch, Alexis Rochas, Conference on optical technologies in biophysics and medicine . 2004

机译：平行荧光相关光谱与具有传统CMOS技术制成的完全集成的单光子2×2检测器阵列
5. A CMOS single-photon avalanche diode array for fluorescence lifetime imaging and microarray applications [D] . Schwartz, David Eric 2008

机译：用于荧光寿命成像和微阵列应用的CMOS单光子雪崩二极管阵列
6. Compact solid-state CMOS single-photon detector array for in vivo NIR fluorescence lifetime oncology measurements [O] . H. A. R. Homulle, F. Powolny, P. L. Stegehuis, 2016

机译：紧凑型固态CMOS单光子探测器阵列用于体内NIR荧光寿命肿瘤学测量
7. Compact solid-state CMOS single-photon detector array for in vivo NIR fluorescence lifetime oncology measurements [O] . Homulle, H., Powolny, E., Stegehuis, P.L., 2016

机译：紧凑型固态CMOS单光子探测器阵列，用于体内NIR荧光寿命肿瘤学测量

Parallel Fluorescence Correlation Spectroscopy with a fully integrated single photon 2 x 2 detector array made with conventional CMOS technology

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