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首页> 外文会议>Instruments, methods, and missions for astrobiology XVII >Complexity of Genetic Sequences Modified by Horizontal Gene Transfer Degraded-DNA Uptake
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Complexity of Genetic Sequences Modified by Horizontal Gene Transfer Degraded-DNA Uptake

机译：水平基因转移和降解的DNA吸收修饰的遗传序列的复杂性

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Horizontal gene transfer has been a major vehicle for efficient transfer of genetic materials among living species and could be one of the sources for noncoding DNA incorporation into a genome. Our previous study of lnc-RNA sequence complexity in terms of fractal dimension and information entropy shows a tight regulation among the studied genes in numerous diseases. The role of sequence complexity in horizontal transferred genes was investigated with Mealybug in symbiotic relation with a 139K genome microbe and Deinococcus radiodurans as examples. The fractal dimension and entropy showed correlation R-sq of 0.82 (N = 6) for the studied Deinococcus radiodurans sequences. For comparison the Deinococcus radiodurans oxidative stress tolerant catalase and superoxide dismutase genes under extracellular dGMP growth condition showed R-sq ～ 0.42 (N = 6); and the studied arsenate reductase horizontal transferred genes for toxicity survival in several microorganisms showed no correlation. Simulation results showed that R-sq ＞ 0.4 would be improbable at less than one percent chance, suggestive of additional selection pressure when compared to the R-sq ～ 0.29 (N = 21) in the studied transferred genes in Mealybug. The mild correlation of R-sq ～ 0.5 for fractal dimension versus transcription level in the studied Deinococcus radiodurans sequences upon extracellular dGMP growth condition would suggest that lower fractal dimension with less electron density fluctuation favors higher transcription level.
机译：水平基因转移一直是在生物物种之间有效转移遗传物质的主要手段，并且可能是将非编码DNA掺入基因组的来源之一。我们先前关于lnc-RNA序列复杂性的分形维数和信息熵方面的研究表明，在许多疾病中，研究基因之间存在严格的调控。用Mealybug与139K基因组微生物共生关系研究了序列复杂性在水平转移基因中的作用，并以放射杜鹃（Deinococcus radiodurans）为例。分形维数和熵表明所研究的Deinococcus radiodurans序列的相关R-sq为0.82（N = 6）。为了进行比较，在细胞外dGMP生长条件下，放射链球菌的耐氧化应激过氧化氢酶和超氧化物歧化酶基因的R-sq〜0.42（N = 6）。研究的砷酸还原酶水平转移基因在几种微生物中的毒性存活没有相关性。模拟结果表明，在Mealybug中研究的转移基因中，R-sq＞ 0.4的可能性小于1％，这是不可能的，这表明与R-sq〜0.29（N = 21）相比，存在额外的选择压力。在细胞外dGMP生长条件下，在研究的Deinococcus radiodurans序列中，R-sq〜0.5与分形维数与转录水平的适度相关性表明，较低的分形维数和较小的电子密度波动有利于较高的转录水平。

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