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首页> 外文会议>Proceedings of the IEEE 4th International Conference on Nano/Molecular Medicine and Engineering >Immune cells-specific delivery of mannan-coated superparamagnetic iron oxide nanoparticles for the detection of metastatic lymph node
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Immune cells-specific delivery of mannan-coated superparamagnetic iron oxide nanoparticles for the detection of metastatic lymph node

机译：免疫细胞特异性递送的甘露聚糖涂层超顺磁性氧化铁纳米颗粒用于检测转移性淋巴结

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Detection of lymph node (LN) metastasis by magnetic resonance imaging (MRI) has obtained clinical significance for treating cancer patients. LN metastasis often happens through regional lymphatic system, leading to distal tumor formation including lungs, liver and bones. Successful imaging of small and microscopic LN metastasis provides the helpful information in deciding the therapeutic option of cancer. Mannan is a water-soluble polysaccharide having high content of D-mannose residues which can be recognized by mannose receptors on activated macrophages and dendritic cells. Mannan-coated superparamagnetic iron oxide nanoparticles (Mannan-SPION) were developed to be specifically delivered to immune cells in lymph node by receptor-mediated endocytosis. Mannan-SPION was proven to be suitable for MR imaging due to small size, excellent stability in ferrofluid, and low cytotoxicity. From the Prussian blue staining, Mannan-SPION was showed their ability to be taken up by immune cells such as macrophage and dendritic cell. In addition mannan-SPION exhibited enhanced targeted delivery efficiency to macrophages in lymph nodes in vivo compared with PVA-SPION. Especially, LN enhancement of Mannan-SPION on MRI was dramatically increased at the later stage after intravenous injection compared with PVA-SPION control, indicative of the potential to successfully detect micrometastasis in LN.
机译：通过磁共振成像（MRI）检测淋巴结（LN）转移已获得治疗癌症患者的临床意义。 LN转移通常通过区域淋巴系统发生，导致远端肿瘤形成，包括肺，肝和骨骼。小而微观的LN转移的成功成像为确定癌症的治疗选择提供了有用的信息。甘露聚糖是具有高含量的D-甘露糖残基的水溶性多糖，其可以被活化的巨噬细胞和树突细胞上的甘露糖受体识别。甘露聚糖涂层的超顺磁性氧化铁纳米颗粒（Mannan-SPION）被开发为通过受体介导的内吞作用特异性地递送至淋巴结中的免疫细胞。 Mannan-SPION具有体积小，在铁磁流体中具有出色的稳定性以及低细胞毒性，因此被证明适合于MR成像。从普鲁士蓝染色中，Mannan-SPION被证明具有被巨噬细胞和树突状细胞等免疫细胞吸收的能力。另外，与PVA-SPION相比，甘露聚糖-SPION对体内淋巴结中的巨噬细胞表现出增强的靶向递送效率。特别是，与PVA-SPION对照相比，静脉注射后后期LN对MRI的Mannan-SPION增强显着增加，表明成功检测LN微转移的潜力。

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