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Integration of microfluidics to electrospray ionization mass spectrometry using a chip-embedded SU-8 electrospray tip

机译:使用芯片嵌入式SU-8电喷雾尖端将微流体与电喷雾电离质谱的整合

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We present two methods for creating polymeric microfluidic devices integrated with electrospray tips for use with mass spectrometry. SU-8 was used to create microfluidic channels and electrospray tips. The planar electrospray tips were located at the end of microfluidic channels and were formed using standard photolithography. The encapsulation of the microfluidic channels was accomplished in one of two ways; by using thermal and press bonding between two SU-8 layers, or by employing a sacrificial layer removal technique. We successfully coupled these microfluidic chips to a mass spectrometer. In particular, the microfluidic device fabricated with the sacrificial layer removal method shows satisfactory electrospray stability.
机译:我们提出了两种方法,用于创建与电喷雾提示集成的聚合物微流体装置,以用于质谱法。 SU-8用于产生微流体通道和电喷雾尖端。平面电喷雾尖端位于微流体通道的末端,并使用标准光刻形成。微流体通道的封装以两种方式之一完成;通过在两个SU-8层之间使用热量并压键,或通过采用牺牲层去除技术。我们成功地将这些微流体芯片耦合到质谱仪。特别地,用牺牲层去除方法制造的微流体装置显示出令人满意的电喷雾稳定性。

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