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首页> 外文会议>International conference on the development of biomedical engineering in Vietnam >Formation of Biodegradable Copolymeric Nanoparticles for Anticancer Drug Delivery
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Formation of Biodegradable Copolymeric Nanoparticles for Anticancer Drug Delivery

机译：形成可生物降解的共聚物纳米颗粒用于抗癌药物递送

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The conventional chemotherapeutic agents have often associated with limitations due to the drug's poor aqueous solubility, side effects resulting from toxicity to healthy tissues. Drug incorporated in nanosized polymeric micelles are promising nanocarrier systems for drug and gene delivery, because the polymeric micelles have several advantages, such as controlled drug release, enhanced tumor-penetrating ability, reduced side toxicity, increased stability, loading capacity and specific-tissue target ability, as well as chemical or physical stimuli-sensitivity. Thus, preparation of nontoxic polymeric micelles may ensure their effectiveness and safety in the clinical use. In this present work, we reported the preparation of nanosized micelles based on amphiphilic copolymer of poly(s-caprolactone)-b-poly(ethylene glycol)-b- poly(E-caprolactone). The polymeric nanoparticles were prepared in aqueous solution by co-solvent precipitation technique at room temperature. Polymeric micelles were measured by dynamic light scattering (DLS) with the size in a range of 70-90 nm and narrow polydispersity. Additionally, the toxicities of polymeric micelles were evaluated by MTT assay and nitric oxide production. These results confirmed low toxic polymeric micelles, suggest that the polymeric micelles hold a potential for anti-cancer drug delivery.
机译：常规的化学治疗剂经常与限制相关由于药物的差的水溶性，副作用得到从毒性对健康组织。在纳米聚合物胶束掺入的药物是有希望的药物和基因递送纳米载体系统，这是因为聚合物胶束具有若干优点，例如可控的药物释放，增强的肿瘤穿透能力，减少侧的毒性，增加的稳定性，负载能力和特异性组织目标能力，以及化学或物理刺激的敏感性。因此，制备的无毒聚合物胶束的可确保其在临床上使用的有效性和安全性。在该目前的工作中，我们报道纳米胶束的基于聚（ε-己内酯）的两亲共聚物的制备-b-聚（乙二醇）-B-聚（ε-己内酯）。在室温下通过共溶剂沉淀技术水溶液中制备聚合物纳米颗粒。聚合物胶束通过动态光散射（DLS）具有一介于70-90纳米和窄的多分散的大小来测量。此外，聚合物胶束的毒性用MTT法和一氧化氮的产生进行评价。这些结果证实低毒聚合物胶束，表明聚合物胶束保持抗癌药物输送的可能性。

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