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首页> 外文会议>The third international conference on the development of biomedical engineering in Vietnam >Formation of Biodegradable Copolymeric Nanoparticles for Anticancer Drug Delivery
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Formation of Biodegradable Copolymeric Nanoparticles for Anticancer Drug Delivery

机译：可生物降解的共聚物纳米粒子的抗癌药物传递的形成。

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The conventional chemotherapeutic agents have often associated with limitations due to the drug's poor aqueous solubility, side effects resulting from toxicity to healthy tissues. Drug incorporated in nanosized polymeric micelles are promising nanocarrier systems for drug and gene delivery, because the polymeric micelles have several advantages, such as controlled drug release, enhanced tumor-penetrating ability, reduced side toxicity, increased stability, loading capacity and specific-tissue target ability, as well as chemical or physical stimuli-sensitivity. Thus, preparation of nontoxic polymeric micelles may ensure their effectiveness and safety in the clinical use. In this present work, we reported the preparation of nanosized micelles based on amphiphilic copolymer of poly(s-caprolactone)-b-poly(ethylene glycol)-b- poly(E-caprolactone). The polymeric nanoparticles were prepared in aqueous solution by co-solvent precipitation technique at room temperature. Polymeric micelles were measured by dynamic light scattering (DLS) with the size in a range of 70-90 nm and narrow polydispersity. Additionally, the toxicities of polymeric micelles were evaluated by MTT assay and nitric oxide production. These results confirmed low toxic polymeric micelles, suggest that the polymeric micelles hold a potential for anti-cancer drug delivery.
机译：由于药物的水溶性差，传统的化学治疗剂常常与局限性有关，副作用是对健康组织的毒性所致。掺入纳米级聚合物微团中的药物是有前途的用于药物和基因递送的纳米载体系统，因为聚合物微团具有多种优势，例如控制药物释放，增强的肿瘤穿透能力，降低的副作用，稳定性，负载能力和特异性组织靶标能力，以及化学或物理刺激敏感性。因此，制备无毒的聚合物胶束可以确保其有效性和安全性。在本工作中，我们报道了基于聚（s-己内酯）-b-聚（乙二醇）-b-聚（ε-己内酯）的两亲共聚物制备纳米胶束。在室温下通过共溶剂沉淀技术在水溶液中制备聚合物纳米颗粒。聚合物胶束通过动态光散射（DLS）测量，尺寸在70-90 nm范围内，多分散性窄。另外，通过MTT测定和一氧化氮的产生来评估聚合物胶束的毒性。这些结果证实了低毒性的聚合物胶束，表明该聚合物胶束具有抗癌药物递送的潜力。

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