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Comparative Characterisation of Susceptibility Weighted MRI for Brain White Matter Lesions in MS

机译:MS中脑白质病变的敏感度加权MRI的比较表征

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MR Images of the brain in Multiple Sclerosis (MS) show regions of signal abnormalities that can provide information for the diagnosis and for the pathogenesis of the disease. Two very commonly used MRI contrasts in this context are the T_1 weighted (T_1-w) and the FLAIR. This study shows that additional information can be extracted from the Susceptibility Weighted MRI (SWI) contrast. In particular, the signal and the contrast of white matter lesions in SWI are examined and compared to T_1-w and FLAIR contrasts. The lesions are analysed into hypo- and hyper-intense. Additionally, the spatial distributions for the two lesion types are computed and summarised with their expected distance from the ventricles. The data from 19 MS patients and 23 controls have been acquired and examined. The results show the presence of two lesion classes in SWI for MS patients, while T_1-w and FLAIR contrast mechanisms present only a single class each. The hypo-intense SWI lesions appear closer to the ventricles and are more correlated to the T_1-w signal rather than the FLAIR signal.
机译:多发性硬化症(MS)中大脑的MR图像显示信号异常的区域,可以为诊断和疾病发病机制提供信息。在此上下文中的两个非常常用的MRI对比是T_1加权(T_1-W)和Flair。本研究表明,可以从易感性加权MRI(SWI)对比度中提取附加信息。特别地,检查了SWI中的白质病变的信号和对比度,并与T_1-W和Flair对比进行比较。病变分析到过枯萎病和超激烈。另外,使用与心室的预期距离计算和总结两个病变类型的空间分布。从19毫秒患者和23个对照的数据进行了预测和检查。结果表明,对于MS患者的SWI存在两种病变类,而T_1-W和Flair造影机制仅存在单一的级别。 Hypo-incense的SWI病变看起来更接近心室,并且与T_1-W信号而不是Flair信号更相关。

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