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Correlation between Clinicopathology and Immunolocalization of Heat Shock Protein 72 and Glycoprotein 96 in Human Hepatocellular Carcinomas

机译:肝细胞癌中临床病理学与糖蛋白96临床病理学和免疫循环化的相关性

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Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 and gp96 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that HSP72 and gp96 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.
机译:热休克蛋白72(HSP72)和糖蛋白96(GP96)在癌组织中高度表达。最近的研究表明HSP72和GP96在胃肠道癌的发展和进展中可能的作用,但详细信息仍然存在暧昧。该研究的目的是探讨人肝细胞癌HSP72和GP96的临床病理学和免疫循环化与GP96之间的相关性。免疫组织化学证明HSP72和GP96在肝细胞癌中具有转移的表达明显高于非转移的癌症。 HSP72和GP96表达与肿瘤浸润,淋巴结和远程转移的存在显着相关。

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