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首页> 外文期刊>African Journal of Microbiology Research >Significance of clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human hepatocellular carcinomas
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Significance of clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human hepatocellular carcinomas

机译：肝细胞癌的临床病理学意义及热休克蛋白72和糖蛋白96的表达

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摘要

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas, but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 and gp96 in human hepatocellular carcinoma. The expression of HSP72 and gp96 was studied in human hepatocellular carcinomas with or without metastasis as well as in tissues adjacent to cancer by way of immunohistochemistry. Messenger ribonucleic acid (RNA)-gene expression levels of HSP72 and gp96 were determined by quantitative real-time real-time reverse transcriptase polymerase chain reaction (RT-PCR) after mRNA extraction. The expression of HSP72 and gp96 has a correlation with the differentiation of hepatocellular carcinoma. HSP72 and gp96 expression in hepatocellular carcinomas with lymph node and organ metastasis was significantly higher than those with non-metastasis. The results indicate that there exists a significant correlation between the expression of HSP72 and gp96 and the progression of hepatocellular carcinomas. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node and remote metastasis. The expression characters of HSP72 and gp96 in tumors may contribute to study the pathogenesis and progression of hepatocellular carcinoma.
机译：热休克蛋白72（HSP72）和糖蛋白96（gp96）在癌症组织中高度表达。最近的研究表明，HSP72和gp96在胃肠道癌的发生和发展中可能发挥作用，但详细信息仍不明确。该研究的目的是研究人肝细胞癌中HSP72和gp96的临床病理与免疫定位之间的相关性。通过免疫组织化学研究了HSP72和gp96在有或没有转移的人肝细胞癌以及癌旁组织中的表达。 mRNA提取后，通过定量实时实时逆转录酶聚合酶链反应（RT-PCR）确定HSP72和gp96的信使核糖核酸（RNA）基因表达水平。 HSP72和gp96的表达与肝细胞癌的分化有关。 HSP72和gp96在具有淋巴结和器官转移的肝细胞癌中的表达显着高于非转移性肝癌。结果表明，HSP72和gp96的表达与肝细胞癌的发展之间存在显着的相关性。 HSP72和gp96表达与肿瘤浸润，淋巴结转移和远处转移密切相关。 HSP72和gp96在肿瘤中的表达特征可能有助于研究肝细胞癌的发生发展。

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