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Food components activating TRPA1

机译：食物组件激活TRPA1

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We searched for novel agonists of TRPA1 in garlic, mioga, galangal, black pepper, and royal jelly by the use of heterogeneously expressed cells. Mioga contained novel and more potent TRPA1 agonists than allyl isothiocyanate (AITC), most famous TRPA1 agonist from wasabi. Garlic and black pepper included both TRPA1 and TRPV1 agonists. A galangal pungent compound had strong activity to TRPA1. Specific fatty acids in royal jelly were TRPA1 active components. In animal studies Intravenous AITC and cinnamaldehyde injection caused adrenaline secretion in rats. Feeding experiments in mice with high-sucrose and high-fat diet resulted in suppression of visceral fat deposition by adding black pepper extract or piperine or cinnamaldehyde. These results suggest that food components activating TRPA1 may enhance energy metabolism or thermogenesis.
机译：我们通过使用异质地表达细胞，搜索了大蒜，Mioga，Galangal，Blackper和Reyal Jelly的新型激动剂。 MioGa含有新颖的和更多有效的TRPA1激动剂，而不是烯丙基异硫氰酸酯（AITC），来自芥末的最着名的TRPA1激动剂。大蒜和黑胡椒包括TRPA1和TRPV1激动剂。 Galangal Pinegent化合物对TRPA1具有很强的活性。皇家果冻的特异性脂肪酸是TRPA1活性组分。在动物研究中，静脉内AITC和肉桂醛注射导致大鼠肾上腺素分泌。通过加入黑辣椒萃取物或哌啶或肉桂醛抑制具有高蔗糖和高脂饮食的小鼠的小鼠实验导致抑制内脏脂肪沉积。这些结果表明，活化TRPA1的食物组分可以增强能量代谢或热生成。

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