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Preliminary results of miniaturized and robust Ultrasound guided diffuse optical tomography system for breast cancer detection

机译:小型化和鲁棒超声引导弥漫性光学断层扫描系统的初步结果乳腺癌检测

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According to the World Health Organization, breast cancer is the most common cancer among women worldwide, claiming the lives of hundreds of thousands of women each year. Near infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response of patients with locally advanced breast cancers. The path toward commercialization of DOT techniques depends upon the improvement of robustness and user-friendliness of this technique in hardware and software. In the past, our group have developed three frequency domain prototype systems which were used in several clinical studies. In this study, we introduce our newly under development US-guided DOT system which is being improved in terms of size, robustness and user friendliness by several custom electronic and mechanical design. A new and robust probe designed to reduce preparation time in clinical process. The processing procedure, data selection and user interface software also updated. With all these improvements, our new system is more robust and accurate which is one step closer to commercialization and wide use of this technology in clinical settings. This system is aimed to be used by minimally trained user in the clinical settings with robust performance. The system performance has been tested in the phantom experiment and initial results are demonstrated in this study. We are currently working on finalizing this system and do further testing to validate the performance of this system. We are aiming toward use of this system in clinical setting for patients with breast cancer.
机译:根据世界卫生组织的说法,乳腺癌是全世界妇女中最常见的癌症,宣称每年数十万名妇女的生活。近红外漫射光学断层扫描(DOT)已经证明了作为分化恶性和良性乳腺病变的辅助方式的巨大潜力,并用于监测局部晚期乳腺癌患者的治疗响应。朝向DOT技术的商业化路径取决于在硬件和软件中提高该技术的鲁棒性和用户友好性。过去,我们的小组开发了三种频域原型系统,用于几项临床研究。在这项研究中,我们在新的开发中介绍了我们引导的DOT系统,这些点在尺寸,鲁棒性和用户友好方面得到了改善,通过多种定制电子和机械设计。一种新的和强大的探头,旨在减少临床过程中的准备时间。还更新了处理过程,数据选择和用户界面软件。通过所有这些改进,我们的新系统更加强大,准确,这是在临床环境中商业化和广泛使用本技术的一步。该系统旨在通过稳健性能的临床环境中的最小训练的用户使用。在幻像实验中测试了系统性能,并在本研究中展示了初始结果。我们目前正在努力完成此系统,并进行进一步测试以验证该系统的性能。我们旨在在乳腺癌患者的临床环境中使用该系统。

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