Oscillating Gene Expressions in Regulatory Networks

机译：在调节网络中振荡基因表达

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We review our work on oscillating genetic expressions in two regulatory biological networks. The first is the Hes1 protein/hes1 mRNA feedback system which regulates timing in many cell types. The second is the p53-mdm2 protein regulatory system which is important for cell control after DNA damage. In both cases, we formulate sub networks of the full genetic network, by identifying the key players in the genetic regulation. We formulate in each case differential equations of two variables and introduce, based on the biological properties, a time-delay in the equations in order to generate the oscillatory behavior. The obtained results are in very good agreement with experimental measurements.

机译：我们回顾了我们在两个调控生物学网络中振荡基因表达的工作。第一个是Hes1蛋白/ hes1 mRNA反馈系统，它可以调节许多细胞类型中的时间。第二个是p53-mdm2蛋白调节系统，对DNA损伤后的细胞控制非常重要。在这两种情况下，我们都通过确定遗传调控中的关键参与者来制定完整遗传网络的子网络。在每种情况下，我们都公式化两个变量的微分方程，并根据生物学特性在方程中引入时间延迟以产生振荡行为。获得的结果与实验测量非常吻合。

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《NATO Advanced Study Institute on Forces, Growth and Form in Soft Condensed Matter: At the Interface between Physics and Biology; 20040324-0403; Geilo(NO)》|2004年|P.195-202|共8页
会议地点 Geilo(NO)
作者
M. H. Jensen; K. Sneppen; G. Tiana;
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作者单位

The Niels Bohr Institute, Blegdamsvej 17, 2100 Copenhagen, Denmark;

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原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
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2. Identification of self-regulatory network motifs in reverse engineering gene regulatory networks using microarray gene expression data [J] . Khalid Mehrosh, Khan Sharifullah, Ahmad Jamil, IET systems biology . 2019,第2期

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3. Identification of self-regulatory network motifs in reverse engineering gene regulatory networks using microarray gene expression data [J] . Khalid Mehrosh, Khan Sharifullah, Ahmad Jamil, IET systems biology . 2019,第2期

机译：使用微阵列基因表达数据鉴定逆向工程基因调控网络中的自我调节网络图案
4. Oscillating Gene Expressions in Regulatory Networks [C] . M. H. Jensen, K. Sneppen, G. Tiana NATO Advanced Study Institute on Forces, Growth and Form in Soft Condensed Matter: At the Interface between Physics and Biology . 2004

机译：监管网络中的振荡基因表达
5. Mathematical Modeling of Cell Type Evolution: Gene Expression and Gene Regulatory Networks [D] . Liang, Cong. 2018

机译：细胞型演化的数学建模：基因表达和基因监管网络
6. Modeling the Zebrafish Segmentation Clock’s Gene Regulatory Network Constrained by Expression Data Suggests Evolutionary Transitions Between Oscillating and Nonoscillating Transcription [O] . Jamie Schwendinger-Schreck, Yuan Kang, Scott A. Holley 2014

机译：受表达数据约束的斑马鱼分段时钟的基因调控网络建模表明振荡转录和非振荡转录之间的进化过渡
7. Inference of SNP-Gene Regulatory Networks by Integrating Gene Expressions and Genetic Perturbations [O] . Dong-Chul Kim, Jiao Wang, Chunyu Liu, 2014

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Oscillating Gene Expressions in Regulatory Networks

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