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Polymer-funetionalised microspheres for immunosensing applications

机译：聚合物功能化微球，用于免疫传感应用

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摘要

Homogeneous polymeric thin layers have been used as functionalising agents on silica microresonators in view of immunosensing applications. We have characterised the microspheres functionalised with poly-L-lactic acid and Eudragit? L100, as an alternative to the commonly used silanes. It is shown that after polymeric functionalization the quality factor of the silica microspheres remains around 107, and that the Q factor is still about 3xl05 after chemical activation and covalent binding of immunogammaglobulin. This functionalising process of the microresonator constitutes a promising step towards the achievement of a highly sensitive immunosensor.
机译：考虑到免疫传感应用，均相聚合物薄层已被用作二氧化硅微谐振器上的功能化剂。我们已经表征了用聚L-乳酸和Eudragit®功能化的微球。 L100，作为常用硅烷的替代品。已经表明，在聚合物官能化之后，二氧化硅微球的品质因数保持在107左右，并且在化学激活和免疫球蛋白的共价结合之后，Q因数仍约为3×10 5。微谐振器的这种功能化过程构成了朝着实现高度灵敏的免疫传感器迈进的有希望的一步。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    S. Soria; F. Baldini; S.Bemeschi; M. Brenci; F. Cosi; A. Giannetti; G. Nunzi Conti; S. Pelli; G.C. Righini; B. Tiribilli;

  • 作者单位

    IFAC-CNR, 'NelloCarrara' Institute of Applied Physics, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence, Italy Centro Studi e Ricerche ' Enrico Fermi', Piazza del Viminale 2, 00184 Rome,Italy;

    IFAC-CNR, 'NelloCarrara' Institute of Applied Physics, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence, Italy;

    IFAC-CNR, 'NelloCarrara' Institute of Applied Physics, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence, Italy;

    IFAC-CNR, 'NelloCarrara' Institute of Applied Physics, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence, Italy;

    IFAC-CNR, 'NelloCarrara' Institute of Applied Physics, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence, Italy;

    IFAC-CNR, 'NelloCarrara' Institute of Applied Physics, via Madonna del Piano 10, 50019 Sesto Fiorentino, Florence,;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
  • 关键词

    microresonators; polymeric thin films; optical sensors;

    机译：微谐振器；聚合物薄膜；光学传感器;

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