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首页> 外文会议>The Second Asian symposium on pharmaceutical sciences and technology >Effect of bile salt-lecithin mixed micelles on gastrointestinal epithelia by Caco-2 cell model
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Effect of bile salt-lecithin mixed micelles on gastrointestinal epithelia by Caco-2 cell model

机译：胆盐-卵磷脂混合胶束对Caco-2细胞模型胃肠道上皮的影响

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摘要

Purpose: To study the effect of bile salt-lecithin mixed micelles on gastrointestinal epithelia from cell-based assay by Caco-2 cell model; Method:The mixed micelles was prepared by rotary evaporation method. The effect on cell viability, proliferation, integrity of gastrointestinal epithelia and apoptosis were evaluated by Caco-2 model. Result:The toxicity increased with the increase of concentration of mixed micelles. The mixed micelles with more than 0.4 mMaffected the cell viability and proliferation significantly when the ratio of lecithin to SDC was lower than 2:1. However, the effect on tight junctions of the mixed micelles with the SDC concentration between 0.2 mM and 0.6 mM were not damage but transient opening. The result of apoptosis also illustrated the mixed micelles with more lecithin induced less apoptosis; ConcIusions:The mixed micelles with the higher concentrations had certain toxicity to Caco-2 cell, while the toxicity declined with the increase of phospholipids.
机译：目的：通过基于Caco-2细胞模型的细胞实验研究胆盐-卵磷脂混合胶束对胃肠道上皮的影响；方法：采用旋转蒸发法制备混合胶束。通过Caco-2模型评估对细胞活力，增殖，胃肠道上皮完整性和细胞凋亡的影响。结果：毒性随着混合胶束浓度的增加而增加。当卵磷脂与SDC的比例低于2：1时，混合的胶束大于0.4 m会显着影响细胞活力和增殖。但是，对SDC浓度在0.2 mM和0.6 mM之间的混合胶束紧密连接的影响不是破坏而是短暂打开。细胞凋亡的结果也说明了混合的胶束与更多的卵磷脂诱导了较少的细胞凋亡。结论：高浓度混合胶束对Caco-2细胞具有一定的毒性，但随着磷脂含量的增加其毒性降低。

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  • 来源
  • 会议地点 Xian(CN)
  • 作者

    YananTan; JianpingQi; Yi Lu; ZongningYin; Wei Wu;

  • 作者单位

    Key Laboratory of Smart Delivery, Ministry of Education PLA, School of Pharmacy, Fudan University,Shanghai201203, China West China School of Pharmacy, Sichuan University, Chengdu610041, Sichuan,China;

    Key Laboratory of Smart Delivery, Ministry of Education PLA, School of Pharmacy, Fudan University,Shanghai201203, China;

    Key Laboratory of Smart Delivery, Ministry of Education PLA, School of Pharmacy, Fudan University,Shanghai201203, China;

    West China School of Pharmacy, Sichuan University, Chengdu610041, Sichuan,China;

    Key Laboratory of Smart Delivery, Ministry of Education PLA, School of Pharmacy, Fudan University,Shanghai201203, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药剂学;
  • 关键词

    Mixed micelles; Bile salt; Lecithin; Caco-2 cell; Toxicity;

    机译：混合胶束;胆盐;卵磷脂; Caco-2细胞;毒性;

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