The recent development of new gold（I） catalytic methods has opened the door to the total syn- thesis of natural products and bioactive complex molecules. We describe a convenient, straightforward, effi- cient and environmentally benign protocol to synthesize the 5-（3-indolyl）oxazole. The new synthetic route was finished in five steps including iodization, N-Boc protection, Sonogashira cross-coupling, gold catalyzed reaction, deprotection using indole as the starting material. The key step was generation of a-oxo carbene via gold-catalyzed intermolecular oxidation of alkynes （2）.%一价金配合物催化的研究，为天然产物和生物活性分子的全合成开辟了新颖简捷的途径．描述了一条简便直接、高效、环境友好的噫唑类天然产物的合成路线．该路线以吲哚为原料，经过碘化，N-Boc保护，Sonogashira偶联，金催化成环反应（72％～88％），脱保护等5步反应合成目标物．关键反应是在金催化下8-甲基喹啉氮氧化物与炔（2）间产生α-羰基金卡宾中间体．
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