Objective To investigate the distribution of producing extended - spectrum β- lacta-mase(ESBLs) bacteria in the hospitals of Yueyang for better comtrol and treatment. Method ProducingESBLs bacteria were detected using standard double - disk spread test. Results Among 227 strains ofEscherichia coli 120 strains of Klebsiella pneumoniase producing ESBLs bacteria accounted for 47.5%(108/227) ,57.5% (69/120),The wards isolated rate of ESBLs in the following order:59.4% in ICUwards,47.9% tumoral diseases wards and 23.9% others. Allproducing ESBLs bacteria were susceptibleto imipenem. No strain was intermediately resistantConclusion This method was simple, credible andcheap. It was suitable for detection of ESBLs routinely in basic clinical micrology laboratory. The mainsource of producing ESBLs bacteria was ICU.To kill these bacteria imipenem can be used first,and thenpiperacilline/tazobactan
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