以氢化三丁锡和丁二酰氯为原料通过还原、分子内重排得到4-Cl-丁内酯,然后与正丁硫醇在碱性条件下发生亲核取代反应得到目标化合物4-丁硫基丁内酯,收率62.4％.中间体4-Cl丁内酯和目标化合物4-丁硫基丁内酯通过氢核磁共振、碳核磁共振和质谱进行确证.%The 4-chlorine butyrolactone was synthesized through reduction, intramolecular rearrangement with tributyl hydride and succinic chloride as raw materials. Then the target compound of 4-thiobutyl butyrolactone was synthesized by the resulting 4-chlo-rine-butyrolactone which was substituted with butanethiol under the basic condition with the yield of 62.4%. The key intermediate 4-chlorine-butyrolactone and the target compound 4-(thioburyl)butyrolactone were confirmed by 'HNMR,13CNMR,MS.
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