Objective To investigate the clinical significance of the anti-cardiolipin antibodies (ACA) Joint D-dimer, and prealbumin (PA) in patients with acute cerebral infarction. Methods 120 patients (acute cerebral infarction group) with a-cute cerebral infarction in our hospital, from January 2010 to December 2011, were divided into light 25 cases, medium 52 cases and severity 43 cases according to the severity of the disease. 46 cases of healthy persons during the same period were chosen as healthy control group. The serum levels of ACA, D-dimer and PA were detected and compared. Results The levels of ACA, D-dimer in acute cerebral infarction group were significantly increased, compared with the healthy control group, while, the levels of PA were crosscurrent (P < 0.01). With increasing severity of acute cerebral infarction, the levels of ACA, D-dimer gradually increased, and the changes of PA, to the contrary, were gradually reduced (P < 0.01). The levels of D-dimer and ACA in positive group increased significantly compared with ACA negative group, while, the levels of PA in ACA positive group were significantly lower than those in ACA negative group (P < 0.01). Conclusion The detection of ACA combined D-dimer with PA in acute cerebral infarction has important clinical significance to judge the condition assessment.%目的 探讨抗心磷脂抗体(ACA)联合D-二聚体和前白蛋白(PA)在急性脑梗死患者中的临床意义.方法 选择2010年1月～2011年12月在我院就诊的急性脑梗患者120例为急性脑梗死组,按照病情的严重程度分为轻型25例,中型52例和重型43例.选取同期健康体检者46例为健康对照组.分别检测血清ACA,D-二聚体和PA的水平,并进行比较.结果 急性脑梗死组的ACA和D-二聚体水平较健康对照组明显升高,而PA水平较健康对照组明显降低(P < 0.01).随着急性脑梗死严重程度的升高,患者ACA和D-二聚体的水平逐渐升高,而PA出现相反的变化,即逐渐降低(P < 0.01).ACA阳性组的D-二聚体水平较ACA阴性组明显升高,而PA水平ACA阳性组较阴性组明显降低(P < 0.01).结论 ACA联合D-二聚体和PA检测对于判断急性脑梗死的病情评估具有重要的临床意义.
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