目的 探讨伴脑型脂肪酸结合蛋白(brain fatty acid binding protein,B-FABP)增高的缺血性卒中(ischemic stroke,IS)患者相关危险因素.方法 共纳入我院85例IS患者,且均证实B-FABP水平>11 μg/L,同时随机抽取90例B-FABP 未增高的IS患者作为对照组.采用免疫透射比浊法检测患者血清B-FABP水平.应用非条件Logistic回归分析进行多因素分析.结果 单因素分析结果表明:两组间男性、冠心病史、高血压病史、糖尿病史、吸烟史、饮酒史、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)差异有统计学意义(P < 0.05);其中男性、高血压病史、冠心病史、糖尿病史、吸烟史、饮酒史、TG、TC、LDL-C与IS患者B-FABP增高呈正相关(P < 0.05);HDL-C与IS患者B-FABP增高的发生呈负相关(P < 0.05).进一步行多因素分析结果表明:高血压病史、糖尿病病史是IS患者B-FABP增高的独立危险因素;HDL-C是IS患者B-FABP增高的保护因素.结论 IS患者B-FABP水平受高血压、糖尿病及HDL-C的影响,对该类人群的高血压、糖尿病等危险因素进行必要的干预具有重要的意义,可能降低IS的发生率、复发率并改善预后.%Objective To investigate the risk factors of increasing in B-FABP in patients with ischemic stroke (IS). Methods 85 IS patients were included in participants group, and both confirmed the B FABP level＞11 μg/L, and 90 cases were randomly B-FABP increased as control group. Adapted Immune transmission method to delect serum B-FABP level of turbidity patients. Logistic regression analysis (unconditional application more factors analysis was used. Results Single factor analysis results showed that the men between the two groups, coronary heart, disease, hypertension history, diabetes medical history, smoking history, drinking history, TG, TC, LDL-C and HDL-C differences exist statistical significance (P＜ 0.0.1); One male, hypertension history, coronary heart disease, diabetes history, smoking history, drinking history, TG, TC, LDL-C and B-FABP have a positive correlation (P ＜ 0.05); HDL-C and B-FABP Increased happened negatively (P ＜ 0.05). Further more factors adapted the analysis results showed that hypertension history, diabetes history were independent risk factors of B-FABP Increased; HDL-C level B-FABP patients IS Increased protection factor. Conclusion B-FABP level of IS patients by high blood pressure, diabetes and HDL-C level, the effects of the people on this kind of high blood pressure, diabetes risk factors such as necessary intervention has an important meaning, may reduce the incidence of recurrence rate IS, and Improve the prognosis.
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