目的：调查介入手术患者围手术期预防使用抗菌药物情况，分析存在的问题。方法回顾性分析医院2012年1月至12月介入手术患者抗菌药物使用情况，剔除原有感染已使用抗菌药物的病例，同时实施干预管理。结果监测患者415例，预防使用抗菌药物27例，使用率6.51%；用药天数1～7 d，平均1.78 d；使用频率排名前5位的依次为头孢孟多、头孢西丁、青霉素、头孢哌酮他唑巴坦、头孢拉定。结论介入手术患者抗菌药物预防性使用情况比较合理，但仍存在用药时间过长、选取不正确等情况，需进一步提高临床医师对抗菌药物使用知识的了解，提高抗菌药物预防性应用的合理性。%Objective To investigate the perioperative prophylactic antibacterial drug use in the patients with intervention surgery and to analyze the existing problems. Methods The retrospective analysis was performed to investigate the perioperative antibacterial drug use in the patients with intervention surgery from January to December 2012. The cases of original infection treated by the antibacterial drugs were excluded and at the same time the intervention management was implemented. Results A total of 415 cases were monitored, 27 cases used the prophylactic antibacterial drugs with the use rate of 6. 51%,the medication time ranged 1-7 d, average 1. 78 d. The top 5 of antibacterial drug use frequency in turn were cefamandole, cefoxitin, penicillin, cefoperazone tazobactam and cephradine. Conclusion The use of perioperative prophylactic antibacterial drug use in the patients undergoing intervention surgery is basically rea-sonable, but there are still some conditions such as too long time of antibacterial drug use and incorrect selection of antibacterial drugs, which needs to further increase the clinical doctors' understanding on the use knowledge of prophylactic antibacterial drugs for enhanc-ing the rationality of prophylactic antibacterial drug use.
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