卵巢癌是继子宫内膜癌和宫颈癌发病率居第三位的妇科恶性肿瘤，其病死率居妇科恶性肿瘤之首。碱性螺旋-环-螺旋( bHLH）转录因子家族成员Twist基因在卵巢癌组织中高度表达，其异常表达在卵巢癌的发生、发展及恶化过程中发挥着重要作用。对Twist基因沉默处理后，卵巢癌细胞的增殖及迁移将受到明显的影响。本文通过结合近年来国内外的研究成果，简述了Twist基因在卵巢癌发生、发展中最新的作用机制。%Ovarian cancer is a gynecologic malignant tumor with morbidity in the third place after endometrial cancer and cervical cancer, its fatality rate ranks first in gynecologic malignant tumors.Twist in the transcription factor of basic helix-loop-helix ( bHLH) family is highly expressed in ovarian cancer tissues, and its abnormal expression plays an important role in the process of occurrence, development and deterioration of the ovary.After silence processing of Twist gene, proliferation and migration of ovarian carcinoma cells will be obviously affected.By combining recent research results at home and abroad, the paper outlines the latest mechanism of Twist gene in the occurrence and development of ovarian cancer.
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