Objective To explore the impact of high flux hemodialysis (HFHD),low-flux hemodialysis com-bined hemoperfusion (LFHD +HP),low-flux hemodialysis (LFHD)on residual renal function of patients with mainte-nance hemodialysis (MHD).Methods Eighty-two cases of uremic patients treated with MHD were retrospectively ana-lyzed.Patients were divided into HFHD group,LFHD +HP group and LFHD group by blood purification methods,.Pa-tients of HFHD group were given Fx80 dialyzer,patients of LFHD +HP group were given F7HPS dialysis and hemoper-fusion HA1 30,and patients of LFHD group were given F7HPS dialyzer.Before and after treatment,urine and blood sam-ples were collected.The residual renal function (RRF)value were calculated and β2 microglobulin,triglycerides,choles-terol C-reactive protein (CRP)levels were detected.Results After treatment,RRF levels of three groups were signifi-cantly decreased (P <0.05),RRF levels of HFHD and LFHD +HP group were significantly higher than LFHD group (P <0.05),there was no statistically significance between HFHD group and LFHD +HP group(P >0.05).After treat-ment,triglycerides,cholesterol,phosphorus,β2-microglobulin and CRP levels of HFHD group and LFHD +HP group were significantly decreased (P <0.05)and significantly lower than LFHD group (P <0.05).and there was no statisti-cally significance between HFHD group and LFHD +HP group (P >0.05).Conclusion The high-flux hemodialysis and hemodialysis combined hemoperfusion can effectively improve the blood lipids and serum phosphate levels of pa-tients with maintenance hemodialysis,protect the RRF and relieve decline of residual renal function.%目的：探讨高通量血液透析（HFHD）、低通量血液透析并血液灌流（LFHD ＋HP）、低通量血液透析（LFHD）对维持性血液透析患者（MHD）残余肾功能的影响。方法回顾性分析行 MHD 治疗82例尿毒症患者的病例资料。根据血液净化方式的不同，将82例患者分为 HFHD 组、LFHD ＋HP 组、LFHD 组。HFHD组使用Fx80透析器，LFHD ＋HP 组使用 F7HPS 透析器和 HA130血液灌流器，LFHD 组使用 F7HPS 透析器。治疗前、后采集患者血、尿标本。计算残余肾功能（RRF）值，并检测患者血液β2微球蛋白、三酰甘油、胆固醇、血磷浓度和C 反应蛋白（CRP）水平。结果治疗后三组 RRF 水平显著降低（P ＜0．05），HFHD 组、LFHD ＋HP 组 RRF 水平显著高于 LFHD 组（P ＜0．05），而 HFHD 组、LFHD ＋HP 组 RRF 水平比较无统计学意义（P ＞0．05）。治疗后， HFHD 组、LFHD ＋HP 组三酰甘油、胆固醇、血磷、β2微球蛋白和 CRP 水平显著降低（P ＜0．05），且各指标水平均显著低于 LFHD 组（P ＜0．05），而 HFHD 组、LFHD ＋HP 组间各指标比较，差异无统计学意义（P ＞0．05）。结论HFHD 和 LFHD ＋HP 可有效改善维持性血液透析患者血脂和血磷水平，保护 RRF，缓解残余肾功能的衰退。
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