Objective:To study the diagnostic value of carbohydrate antigen 153(CA153),serum ferritin(SF) and tissue poly-peptide specific antigen(TPS) in breast cancer. Methods: The serum levels of CA153,SF and TPS were detected by enzyme-linked immunosorbent assay(ELISA) in 38 patients with breast cancer,28 patients with benign breast tumor and 20 healthy women. Results: The serum levels of the 3 tumor markers in breast cancer group were significantly higher than those in the other two groups(P<0. 01). The levels of SF and TPS increased with the increase of clinical stage. The sensitivities of CA153,SF and TPS in the diagnosis of breast cancer were 52. 6%,60. 5% and 65. 8% respectively. The sensitivity of the 3 tumor markers in combination was 86. 8% in breast cancer diagnosis. Conclusions: CA153,SF and TPS have diagnostic value in breast cancer. The combination of the 3 markers can significantly improve the accuracy of breast cancer diagnosis.%目的:探讨血清糖类抗原153(carbohydrate antigen 153,CA153)、铁蛋白(serum ferritin,SF)、组织多肽特异性抗原(tissue polypeptide specific antigen,TPS)对乳腺癌诊断的意义.方法:用酶联免疫吸附试验(enzyme-linked immunosorbent assay, ELISA)分别检测38例乳腺癌患者、28例乳腺良性肿瘤患者和20例正常健康女性血清CA153、SF、TPS水平.结果:血清CA153、SF、TPS水平在乳腺癌组中显著高于乳腺良性肿瘤组和正常对照组(P＜0.01)；SF、TPS水平随着乳腺癌临床分期的增加而增高；CA153、SF、TPS对乳腺癌诊断的敏感性分别为52.6％、60.5％、65.8％,三者联合检测对乳腺癌诊断的敏感性为86.8％.结论:CA153、SF、TPS对乳腺癌诊断有一定价值,TPS与CA153、SF联合检测有互补性,可提高对乳腺癌诊断的敏感性.
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