目的：对228例淋病患者淋病奈瑟球菌的耐药性进行探讨分析。方法：对淋病奈瑟球菌采用纸片扩散法（K －B 法）进行检测，对β内酰胺酶采用头孢硝噻吩纸片法进行检测。结果：228株淋病奈瑟球菌中，来自宁海县中医医院的有72株，其中β内酰胺酶检测阳性的有19株；来自湖州市妇幼保健院的有156株，其中β内酰胺酶检测阳性的有41株。所有检测为阳性的菌株在228株菌株中占26.32％。来自所有的淋病奈瑟球菌菌株对5种抗菌药物的耐药性有明显的区别，菌株对四环素、青霉素和环丙沙星的耐药性比较高，对头孢曲松、大观霉素的耐药性比较低一些。结论：根据研究数据，在临床上应当避免使用四环素、青霉素等作为抗菌的首选药物，应适当选取头孢曲松、大观霉素作为临床治疗淋病奈瑟球菌感染的首选药物。%Objectives:To analyze the Neisseria gonorrhoeae resistance of gonorrhea among 228 patients. Methods:Disk diffusion method (KB method)was used to detect Neisseria gonorrhoeae.The nitrocefin paper method was used to detect β-lactamase.Results:Among the 228 Neisseria gonorrhoeae,there were 72 from Ning-hai County Chinese Medicine Hospital,among which 19 positive β-lactamase were tested;156 Neisseria gonor-rhoeae were from Huzhou City,MCH,among which 41 positive β-lactamase were tested.Positive detection rate in 228 strains accounted for 26.32%.The resistance of all strains for Neisseria gonorrhoeae to five kinds of antibacteri-al drugs had significant difference.Resistance to tetracycline,penicillin and ciprofloxacin resistance was relatively high and resistance to ceftriaxone,spectinomycin was relatively low.Conclusion:According to research data,tetra-cycline,penicillin and other drugs should be avoided as the preferred antibacterial drugs in clinic,while ceftriaxone and spectinomycin should be properly selected as the first drug choice for the treatment of Neisseria gonorrhoeae in-fection in clinic.
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