目的 探讨某院综合重症监护室(ICU)住院患者发生多重耐药菌(MDRO)感染情况及干预效果.方法 对该综合ICU进行目标性监测并制定相应干预措施,比较干预前后MDRO医院感染发生情况.结果 共调查1 184例患者,发生MDRO医院感染77例次,社区感染109例次;检出MDRO 186株,检出率为15.71%,菌种以鲍曼不动杆菌(43.55%)、耐甲氧西林金黄色葡萄球菌(29.57%)、铜绿假单胞菌(23.66%)为主.MDRO医院感染部位以呼吸道感染率(79.22%,61/77)最高.经干预后,综合ICU医院感染MDRO的发生率由6.92%(38/549)降至4.25%(27/635),差异有统计学意义(χ2=4.04,P＜0.05).结论 MDRO是综合ICU患者医院感染的重要病原菌,采取有效干预措施可减少其医院感染的发生.%Objective To evaluate the occurrence and intervention effectiveness on multidrug-resistant organism (MDRO) infection in general intensive care unit (ICU) patients. Methods Targeted monitor and proper measures on general ICU were performed, the occurrence of MDRO infection before and after infection was compared. Results A total of 1 184 patients were investigated, there were 77 cases of healthcare-associated infection(HAI) and 109 community-associated infection, 186 (15. 71 %) isolates of MDROs were isolated, the main bacteria were Acineto-bacter bawnannii (43.55%), methicillin-resistant Staphylococcus aureus (29. 57%), and Pseudomonas aeruginosa (23. 66%). The major infection site was respiratory tract (79. 22%, 61/77). After intervention, MDRO infection in this ICU decreased from 6. 92% (38/549) to 4. 25% (27/635), the difference was significant (x2=4. 04, P＜ 0. 05). Conclusion MDROs are important pathogens in HAI in general ICU patients, effective measures can reduce the occurrence of MDRO infection.
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