目的：探讨开展抗菌药物专项整治活动对中山市人民医院（以下简称为“我院”）烧伤科住院患者使用抗菌药物情况的影响。方法：回顾性统计、分析我院烧伤科开展专项整治前、后出院患者的临床资料和抗菌药物使用情况。结果：经过专项整治，我院烧伤科住院患者抗菌药物使用率从整治前的100�00％下降至96�33％；抗菌药物销售金额占药品销售总金额的比例从整治前的61�78％下降至25�56％；抗菌药物使用强度（AUD）从整治前的162�35 DDDs／（100人·d）下降至55�78 DDDs／（100人·d）；抗菌药物的总DDDs由3335�55下降至1262�72；病原菌对常用抗菌药物的耐药率降低；单药使用率从76�27％上升至83�18％，但二联用药率和三联用药率的下降幅度不大，分别从16�10％下降至8�41％、从5�09％下降至4�68％。结论：专项整治对合理使用抗菌药物有明显的促进作用，但仍需加强对使用抗菌药物的监管。%OBJECTIVE: To evaluate the effects of special rectification on rational use of antibiotics in our hospital. METHODS: The clinical data and the antibiotic use of the discharged burn patients before and after rectification( Jul.⁃Sept. period of 2010 versus Jul.⁃Sept. period of 2012 ) were analyzed retrospectively. RESULTS:The rate( mean value) of antibiotic use was reduced from 100�00% before rectification to 96�33% after rectification;the proportion of antibiotic cost in total drug cost decreased from 61�78% to 25�56%; AUD decreased from 162�35 DDDs/(100 persons·day) to 55�78 DDDs/(100 persons·day); the total DDDs of antibacterials decreased from 3 335�55 to 1 262�72 . The resistance rates of pathogens to common antibiotics were reduced;the rate of single⁃drug use was up from 76�27% to 83�18% after rectification, but the rate of two⁃drug and three⁃drug use was down from 16�10% to 8�41% and that of three⁃drug was down from 5�09% to 4�68%. CONCLUSIONS: The special rectification activity promoted the antibiotic use and achieved primary outcome in burn department of our hospital;however, the rate of antibiotic use, AUD and the proportion of antibiotics in total in terms of drug cost failed to meet the ideal requirements;therefore, strengthened supervision on antibiotic use remains to be done.
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