Objective To find out the pattern of variation of oxidative stress and inflammation mediators levels in the workers exposed to silica dust and silicosis patients .Method 70 hotel staff members were chosen as the control group .100 workers exposed to SiO2 for at least 1 year in a foundry were chosen as the dust-exposure group.110 cases with silicosis (52 cases of phase I silicosis, 39 cases of phase II and 19 cases of III phase) were chosen as the silicosis group , and 24 cases with phase 0 +silicosis in the foundry were chosen as the experimental group .The superoxide dismutase ( SOD ) , glutathione peroxidase (GSH-Px), nitric oxide (NO), lipid malondialdehyde (MDA) and transforming growth factor-β1(TGF-β1), tumor necrosis factor-alpha ( TNF-α) levels in serum of all groups were determined .Findings Compared with the control group, the SOD decreased in the dust-exposed group or the silicosis group , while GSH-Px,NO, MDA,TGF-β1 and TNF-αincreased significantly .Conclusion GSH-Px, TGF-β1 and TNF-αexpression is correlated with disease progress .It can be considered as a precursor of relapse of the disease .%目的：探讨连续性肾脏替代（ continuous renal replacement therapy ， CRRT ）与间歇性血液透析（ intermittent hemodialysis，IHD）治疗重症急性肾损伤（acute kidney injury，AKI）的疗效，分析预后影响因素。方法230例重症AKI患者随机分为两组各115例，分别采取CRRT和IHD治疗，比较两组患者的治疗效果，分析重症AKI患者的预后影响因素。结果两组患者治疗后BUN、Scr、APACHE-Ⅱ评分均显著下降，且CRRT组下降更显著（P＜0．01）；两组患者治疗后HCO3－均显著上升，CRRT组上升更显著（P＜0．01）。年龄（OR＝3．105）、器官衰竭数目（OR＝4．718）、APACHE-Ⅱ评分（OR＝3．693）、合并严重基础疾病（OR＝7．847）是重症AKI患者死亡的独立高危因素（P＜0．05）。结论与IHD比较，CRRT治疗重症AKI疗效更为显著；年龄、器官衰竭数目、APACHE-Ⅱ评分、合并严重基础疾病是重症AKI患者死亡的独立高危因素。
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