Objective: To investigate the short-term effect of butylphthalide joint atorvastatin treatment on blood lipid levels of very elderly patients with cerebral infarction.Methods:The clinical data of 200 cerebral infarction patients (≥80 years old) undergoing drug therapies systematically were reviewed. Ninety eight cases in the statins group were treated with atorvastatin and antiplatelet drugs, 102 cases in the butylphthalide plus statins group were administrated by butylphthalide plus atorvastatin and antiplatelet drugs. hTe level of lipid biochemical parameters of each case pre- and post-treatment in above 2 groups was assayed. The short-term efficacy of butylphthalide plus atorvastatin on improving blood lipid levels of elderly with ischemic stroke was evaluated.Results: Atfer 1 week systematic medication therapy, the levels of total cholesterol (TC) and low-density lipoprotein (LDL) in statins group decreased markedly (P<0.05), while the levels of triglycerides (TG), high-density lipoprotein (HDL) and lipoprotein (a) [Lp(a)] in this group had no signiifcant change (P>0.05). For butylphthalide plus statins group, the levels of TG, TC and LDL had been decreased signiifcantly (P<0.05), both HDL and Lp(a) had no signiifcant difference compared with those of pre-treatment (P>0.05). Furthermore, the decrease extents of TG, TC and LDL in butylphthalide plus statins group were more signiifcantly than those in statins group (P<0.05).Conclusion:Short-term therapy by butylphthalide plus atorvastatin can signiifcantly improve the levels of TG, TC and LDL of very elderly patients with cerebral infarction, but no effect on HDL and Lp(a) levels.%目的：探讨丁苯酞联合阿托伐他汀短期治疗对高龄老年脑梗死患者血脂水平的影响。方法：收集筛选我院神经内科2012年7月至2014年6月入院治疗的高龄老年(≥80岁)脑梗死病例200例，按治疗方法分为2组：他汀组：98例，予阿托伐他汀降脂、抗血小板药物改善脑循环等综合治疗；丁苯酞+他汀组：102例，在他汀组的治疗基础上加用丁苯酞治疗。检测2组患者治疗1周前后的血脂生化指标水平，分析丁苯酞联合阿托伐他汀短期治疗对高龄脑梗死患者血脂水平的影响。结果：他汀组治疗后的总胆固醇(TC)和低密度脂蛋白(LDL)水平显著降低(P<0.05)，三酰甘油(TG)、高密度脂蛋白(HDL)和脂蛋白a[lipoprotein (a)，Lp(a)]水平治疗前后无显著变化(P>0.05)；丁苯酞+他汀组治疗后的TG、TC、LDL水平显著降低(P<0.05)，HDL、Lp(a)水平无显著变化(P>0.05)；丁苯酞+他汀组TG、TC、LDL水平降低的幅度显著高于他汀组(P<0.05)。结论：丁苯酞联合阿托伐他汀短期治疗可显著改善高龄老年脑梗死患者的TG、TC、LDL水平，而对HDL、Lp(a)水平无显著影响。
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