A new series of chiral phase-transfer catalysts 7a-7h were designed and synthesized from L-proline with moderate to good yields. The catalytic activity of 7a-7h for the asymmetric alkylation of glycine Schiff bases was evaluated, and some interesting relationships between structure and catalytic activity were revealed.%以L-脯氨酸为起始物设计了一类新型手性相转移催化剂,并基于对映选择性催化的结果对催化剂的结构进行优化.最终合成了8个新型手性螺环季铵盐类相转移催化剂,用于催化N-二苯亚甲基甘氨酸叔丁酯的不对称烷基化反应,高产率得到烷基化产物,ce值最高达21%.
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