目的 探讨药物性肝损害的临床特点及治疗措施.方法 对216例药物性肝损害患者的临床资料进行回顾性分析.结果 216例药物性肝损害中,抗生素(包括抗结核药物)最多,占60.3%(130/216),次为抗肿瘤药物,占15.7%(34/216);肝损害以肝细胞型多见,占49.5%(107/216),胆汁淤积型次之,占29.6%(64/216),混合型占20.8%(45/216);主要临床表现有乏力、纳差、黄疸、上腹部不适、皮疹、发热.实验室检查丙氨酸氨基转移酶(ALT)升高216例(100.0%);碱性磷酸酶(ALP)升高109例(50.5%);总胆红素(TB)升高58例(26.9%).临床治愈165例,好转35例,自动出院11例,死亡5例.结论 引起药物性肝损害的药物种类较多,应及早发现及时治疗.%Objective To analyze the clinical characteristics and the treatment of drug induced liver injury. Methods Two hundred and sixteen patients with drug induced liver injury admitted to our hospital from 2005 - 10 to 2011 - 10 were reviewed retrospectively. Results A variety of drugs were involved in causing liver disease. The common offending agents were antimicrobial agents(60. 3% ,130/216) , and antineoplastic(15. 7% ,34/216) ; 49. 5% (107/216) was classified as hepatocellular type, 29.6% (64/216) as cholestatic type, and 20.8% (45/216) as mixed type. The main clinical manifestation were fatigue, jaundice, anorexia, epigastrium uncomfortable, rash, fever. The laboratory tests of liver functions showed increased levels of ALT( 100. 0% ) , ALP(50. 5% , 109/216) and TB ( 26. 9% , 58/216 ). 165 patients recovered, 32 patients improved, and 2 patients died. Conclusion A variety of drugs can induce liver disease.
展开▼
