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首页> 美国卫生研究院文献>Indian Journal of Hematology Blood Transfusion >Evaluation of the Sensitivity and Specificity of Use of Glucose and pH for Bacterial Screening of Platelet Concentrates Compared to the Bact/Alert
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Evaluation of the Sensitivity and Specificity of Use of Glucose and pH for Bacterial Screening of Platelet Concentrates Compared to the Bact/Alert

机译：与细菌/警戒物相比评估葡萄糖和pH值用于细菌筛查血小板浓缩物的敏感性和特异性

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Bacterial contamination of blood components is the major infectious risk in transfusion medicine. Since platelets should be stored at room temperature that makes them an excellent growth medium for bacteria; it is mentioned as a major problem in transfusion medicine. Transfusion risk of a bacterial contaminated platelet concentrate is higher than viral pathogen such as HIV, HBV, HCV and HTLV. The objective of this study was to evaluation of the sensitivity and specificity of use of glucose and pH for bacterial screening of platelet concentrates compared to the Bact/Alert. 1332 platelet concentrates were screened by the Bact/Alert system for aerobic and anaerobic bacterial contamination. Bacterial contamination was also evaluated by using urine reagent strips (Multistix10 SG Bayer) and culture methods. Moreover PH screening with a pH meter (Metrohm 744 Swiss) and glucose was also used for detection of bacterial contamination. The rate of bacterial contamination detected by the Bact/Alert system in platelet concentrates was 25 in 1332 (1.9 %). It contained 15 (1.1 %) for aerobic bacteria and 10 (.8 %) for anaerobic bacteria. 226 of 1332 were considered as containing bacteria by using urine reagent strips. Six of the 226 units were also positive by the Bact/Alert system. Three of those units were culture positive for aerobic bacteria and three for anaerobic. The result of platelet concentrates that underwent pH screening by use of pH meter and a pH portion of urine reagent strips was the same. The sensitivity and specificity of considering glucose alone for detection of bacterial contamination were 12 and 98 % respectively. For pH alone, these were 24 and 83 %. For glucose and/or pH, these were 24 and 83 %; and for combination of glucose and pH, these were 12 and 98 %. Our results showed use of glucose/pH strips would improve the safety of blood products and should be encouraged.
机译：血液成分的细菌污染是输血医学的主要传染风险。由于血小板应在室温下保存，这使其成为细菌的极佳生长培养基；它被认为是输血医学中的一个主要问题。细菌污染的血小板浓缩液的输血风险高于病毒病原体，例如HIV，HBV，HCV和HTLV。这项研究的目的是评估与Bact / Alert相比，葡萄糖和pH值用于细菌筛选血小板浓缩物的敏感性和特异性。通过Bact / Alert系统筛选了1332种血小板浓缩物的需氧和厌氧细菌污染。还通过使用尿液试剂条（Multistix10 SG Bayer）和培养方法评估细菌污染。此外，还使用pH计（Metrohm 744 Swiss）和葡萄糖进行PH筛查，以检测细菌污染。通过Bact / Alert系统在浓缩血小板中检测到的细菌污染率为13分之25（1.9％）。其中好氧细菌含量为15（1.1％），厌氧菌含量为10（.8％）。通过使用尿液试剂条，将1332个中的226个视为含有细菌。 226个单位中有六个单位的Bact / Alert系统也呈阳性。其中三个单位的需氧菌培养阳性，三个单位的厌氧菌培养阳性。通过使用pH计和尿液试剂条的pH部分进行pH筛选的浓缩血小板的结果是相同的。仅考虑使用葡萄糖检测细菌污染的敏感性和特异性分别为12％和98％。仅就pH而言，分别为24％和83％。对于葡萄糖和/或pH，分别为24％和83％；对于葡萄糖和pH的组合，分别为12％和98％。我们的结果表明，使用葡萄糖/ pH试纸条可提高血液制品的安全性，应予以鼓励。

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