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首页> 美国卫生研究院文献>Nutrients >The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study
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The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study

机译：补充AA和DHA的婴儿配方食品对不同FADS基因型婴儿脂肪酸水平的影响：COGNIS研究

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Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Infants with specific genotypes may require different amounts of these fatty acids (FAs) to maintain an adequate status. The aim of this study was to determine the effect of an infant formula supplemented with AA and DHA on FAs of infants with different FADS genotypes. In total, 176 infants from the COGNIS study were randomly allocated to the Standard Formula (SF; n = 61) or the Experimental Formula (EF; n = 70) group, the latter supplemented with AA and DHA. Breastfed infants were added as a reference group (BF; n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age. FADS minor allele carriership in formula fed infants, especially those supplemented, was associated with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected, possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.
机译：脂肪酸去饱和酶（FADS）基因的多态性会影响花生四烯酸（AA）和二十二碳六烯酸（DHA）的酸浓度（在生命早期至关重要）。具有特定基因型的婴儿可能需要不同量的这些脂肪酸（FAs）才能维持适当的状态。这项研究的目的是确定补充AA和DHA的婴儿配方食品对具有不同FADS基因型婴儿的FA的影响。来自COGNIS研究的总共176名婴儿被随机分配到标准配方奶粉（SF; n = 61）或实验配方奶粉（EF; n = 70）组中，后者补充有AA和DHA。加入母乳喂养婴儿作为参考组（BF； n = 45）。从3个月大时收集的脸颊细胞分析FAs和FADS多态性。在配方奶喂养的婴儿中，特别是在补充营养的婴儿中，FADS的次要等位基因携带与去饱和酶活性下降，AA和DHA水平降低有关。母乳喂养的婴儿没有受到影响，可能受到了母乳中AA和DHA含量较高的影响。补充增加了AA和DHA水平，但主要在主要等位基因携带者中。总之，婴儿FADS基因型可能有助于缩小母乳喂养和配方奶喂养婴儿之间AA和DHA浓度的差距。

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