• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Comparative Medicine >Edema and Tetraparesis in a Miniature Pig after Allogeneic Hematopoietic Cell Transplantation
【2h】

Edema and Tetraparesis in a Miniature Pig after Allogeneic Hematopoietic Cell Transplantation

机译：异基因造血细胞移植后小型猪的水肿和四肢瘫痪

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A 3-mo-old, 12-kg, intact, miniature pig presented with severe neurologic signs on day 8 after hematopoietic cell transplantation. This pig had received an immunosuppressive regimen before transplantation that included an antiCD3 immunotoxin for T-cell depletion, 100 cGy of total-body irradiation, and cyclosporine for 45 d. The pig began exhibiting erythematous lesions on posttransplantation day 7. He also demonstrated increased conscious proprioceptive deficits and recumbency but normal mentation. Neurologic signs worsened over several days; the pig became lethargic but remained afebrile. Conjunctival swelling developed on posttransplantation day 9, which subsequently spread to the animal's head, ears and hocks by day 10. Analgesics were given for pain, and cyclosporine levels were decreased. Despite the measures taken, neurologic signs progressed. Given the worsening subcutaneous edema and neurologic status, Escherichia coli infection was suspected, and treatment with a third-generation cephalosporin was instituted. The clinical signs resolved within 12 h after the start of antibiotics. ‘Shiga-like’ toxin from E. coli can cause peracute toxemia and induce ataxia, paralysis, and recumbency. Other common and pathognomonic findings include periocular edema and variable edema in other subcutaneous regions. A fecal sample demonstrated an overgrowth of gram-negative, lactose-fermenting colonies. On the basis of the clinical presentation, exclusion of other potential conditions compatible with edema and neurologic diseases, physical exam findings, microbiology and the resolution of signs after therapy, the pig was diagnosed with edema disease.
机译：造血细胞移植后第8天，一只3个月大，体重12公斤的完整小型猪表现出严重的神经系统症状。该猪在移植前已接受了免疫抑制方案，其中包括用于T细胞耗竭的抗CD3免疫毒素，100 cGy全身照射和环孢素45 d。猪在移植后第7天开始出现红斑性病变。他还表现出自觉的本体感受缺陷和卧床现象增加，但精神状态正常。几天后神经系统症状恶化；猪昏昏欲睡，但保持发热。结膜肿胀在移植后第9天发展，然后在第10天扩散到动物的头部，耳朵和臀部。止痛药用于止痛，环孢素水平降低。尽管采取了措施，神经系统症状仍在发展。考虑到皮下水肿和神经系统状况的恶化，怀疑有大肠杆菌感染，并开始使用第三代头孢菌素治疗。开始使用抗生素后12小时内临床症状消失。大肠杆菌中的“志贺样”毒素可引起急性毒血症，并导致共济失调，瘫痪和卧倒。其他常见和病理检查结果包括其他皮下区域的眼周水肿和可变性水肿。粪便样本显示革兰氏阴性乳糖发酵菌落过度生长。根据临床表现，排除与水肿和神经系统疾病相适应的其他潜在疾病，体格检查结果，微生物学和治疗后体征的缓解，猪被诊断为水肿病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号