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首页> 外文期刊>Comparative Medicine >Edema and Tetraparesis in a Miniature Pig after Allogeneic Hematopoietic Cell Transplantation
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Edema and Tetraparesis in a Miniature Pig after Allogeneic Hematopoietic Cell Transplantation

机译：异基因造血细胞移植后小型猪的水肿和四肢瘫痪

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A 3-mo-old, 12-kg, intact, miniature pig presented with severe neurologic signs on day 8 after hematopoietic cell transplantation. This pig had received an immunosuppressive regimen before transplantation that included an antiCD3 immunotoxin for T-cell depletion, 100 cGy of total-body irradiation, and cyclosporine for 45 d. The pig began exhibiting erythematous lesions on post-transplantation day 7. He also demonstrated increased conscious proprioceptive deficits and recumbency but normal mentation. Neurologic signs worsened over several days; the pig became lethargic but remained afebrile. Conjunctival swelling developed on posttransplantation day 9, which subsequently spread to the animal's head, ears and hocks by day 10. Analgesics were given for pain, and cyclosporine levels were decreased. Despite the measures taken, neurologic signs progressed. Given the worsening subcutaneous edema and neurologic status, Escherichia coli infection was suspected, and treatment with a third-generation cephalosporin was instituted. The clinical signs resolved within 12 h after the start of antibiotics. 'Shiga-like' toxin from E. coli can cause peracute toxemia and induce ataxia, paralysis, and recumbency. Other common and pathognomonic findings include periocular edema and variable edema in other subcutaneous regions. A fecal sample demonstrated an overgrowth of gram-negative, lactose-fermenting colonies. On the basis of the clinical presentation, exclusion of other potential conditions compatible with edema and neurologic diseases, physical exam findings, microbiology and the resolution of signs after therapy, the pig was diagnosed with edema disease.
机译：造血细胞移植后第8天，一只3个月大，体重12公斤的完整小型猪呈现出严重的神经系统症状。该猪在移植前接受了免疫抑制方案，其中包括针对T细胞耗竭的抗CD3免疫毒素，100 cGy全身辐射和环孢素45 d。猪在移植后第7天开始出现红斑性病变。他还表现出自觉的本体感受缺陷和卧位增加，但精神状态正常。几天内神经系统症状恶化;猪昏昏欲睡，但保持发热。移植后第9天出现结膜肿胀，随后在第10天传播到动物的头部，耳朵和臀部。止痛药用于镇痛，环孢素水平降低。尽管采取了措施，神经系统症状仍在发展。考虑到皮下水肿和神经系统状况的恶化，怀疑有大肠杆菌感染，并开始使用第三代头孢菌素治疗。开始使用抗生素后12小时内临床症状消失。大肠杆菌中的“志贺样”毒素可引起急性毒血症，并导致共济失调，瘫痪和卧倒。其他常见的和病理性的发现包括其他皮下区域的眼周水肿和可变性水肿。粪便样本显示革兰氏阴性，乳糖发酵菌落过度生长。根据临床表现，排除与水肿和神经系统疾病相适应的其他潜在疾病，体格检查结果，微生物学和治疗后体征的缓解，猪被诊断为水肿病。

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