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Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells

机译：二甲双胍介导的生长抑制涉及抑制人胰腺癌细胞中的IGF-I受体信号通路

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BackgroundEpidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent population studies indicate that the incidence of pancreatic cancer is reduced among diabetics taking metformin. In this study, the effects of exposure of pancreatic cancer cells to high glucose levels on their growth and response to metformin were investigated.

机译：背景流行病学研究表明，2型糖尿病与肥胖，高血糖和高胰岛素血症相关的疾病以及胰腺癌的风险之间存在直接的联系。在诊断时，多达80％的胰腺癌患者出现新发2型糖尿病或糖耐量降低。最近的人群研究表明，服用二甲双胍的糖尿病患者胰腺癌的发病率降低。在这项研究中，研究了胰腺癌细胞暴露于高葡萄糖水平对其生长和对二甲双胍反应的影响。

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期刊名称 BMC Cancer
作者
Emelie Karnevi; Katarzyna Said; Roland Andersson; Ann H Rosendahl;
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年(卷),期 2013(13),-1
年度 2013
页码 235
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Pancreatic cancer Type 2 diabetes mellitus Hyperglycaemia Metformin Insulin-like growth factor (IGF) Signalling;

机译：胰腺癌;2型糖尿病;高血糖症;二甲双胍;胰岛素样生长因子（IGF）;信号传导;

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专利

1. Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells [J] . Emelie Karnevi, Katarzyna Said, Roland Andersson, BMC Cancer . 2013,第1期

机译：二甲双胍介导的生长抑制涉及抑制人胰腺癌细胞中的IGF-I受体信号通路
2. Growth inhibition of pancreatic cancer cells by histone deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo [J] . ChienW., LeeD.H., ZhengY., Molecular Carcinogenesis . 2014,第9期

机译：组蛋白脱乙酰基酶抑制剂贝利司他通过抑制多种途径（包括体内和体外的HIF，NFkB和mTOR信号传导）抑制胰腺癌细胞的生长
3. Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways [J] . Yang Zhenhua, Liu Ying, Shi Changzheng, Oncology reports . 2017,第2期

机译：PTEN / AKT信号传导的抑制减少了TubB3和TOP2a的表达，随后通过ATP和Caspase-3信号通路抑制人乳腺癌MCF-7细胞中的细胞生长和诱导凋亡
4. Towards a Serum-free Culture Medium: Identifying Human Growth Receptors and Signaling Pathways that regulate Cell Proliferation in Human Mesenchymal Stem Cells (MSCs) [C] . Nicholas Xue Wei Tan, Felicia Soo Lee Ng, Vivek Tanavde International Conference on Bioinformatics and Computational Biology . 2007

机译：朝向无血清培养基：鉴定人生长受体和调节人间充质干细胞中细胞增殖的信号通路（MSC）
5. SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via inhibition of the phosphoinositide 3-kinases pathway [D] . Moore, Robert L. 2011

机译：SIRT1通过抑制磷酸肌醇3激酶途径抑制雌激素信号传导，配体独立的雌激素受体α介导的转录和乳腺癌细胞的增殖
6. Growth Inhibition of Pancreatic Cancer Cells by Histone Deacetylase Inhibitor Belinostat Through Suppression of Multiple Pathways Including HIF NFkB and mTOR Signaling In Vitro and In Vivo [O] . Wenwen Chien, Dhong Hyun Lee, Yun Zheng, -1

机译：通过在体外和体内抑制包括HIFNFKB和MTOR信号传导的多种途径通过组蛋白脱乙酰化酶抑制剂Belinostat对组蛋白脱乙酰酶抑制剂Belinostat的生长抑制
7. Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells [O] . Emelie Karnevi, Katarzyna Said, Roland Andersson, 2013

机译：二甲双胍介导的生长抑制涉及抑制人胰腺癌细胞中的IGF-I受体信号通路

Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells

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