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The Use of Endophytes to Obtain Bioactive Compounds and Their Application in Biotransformation Process

机译:内生菌在生物活性化合物中的应用及其在生物转化过程中的应用

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摘要

Endophytes are microorganisms that reside asymptomatically in the tissues of higher plants and are a promising source of novel organic natural metabolites exhibiting a variety of biological activities. The laboratory of Bioaromas (Unicamp, Brazil) develops research in biotransformation processes and functional evaluation of natural products. With the intent to provide subsidies for studies on endophytic microbes related to areas cited before, this paper focuses particularly on the role of endophytes on the production of anticancer, antimicrobial, and antioxidant compounds and includes examples that illustrate their potential for human use. It also describes biotransformation as an auspicious method to obtain novel bioactive compounds from microbes. Biotransformation allows the production of regio- and stereoselective compounds under mild conditions that can be labeled as “natural,” as discussed in this paper.
机译:内生细菌是无症状地存在于高等植物组织中的微生物,并且是展现出多种生物学活性的新型有机天然代谢产物的有希望的来源。 Bioaromas实验室(巴西Unicamp)致力于生物转化过程和天然产物功能评估的研究。为了为与之前引用的领域有关的内生微生物的研究提供补贴,本文特别关注内生菌在生产抗癌,抗微生物和抗氧化剂化合物中的作用,并举例说明了其在人类中的潜在应用。它还将生物转化描述为一种从微生物中获得新型生物活性化合物的吉祥方法。如本文所述,生物转化可以在温和条件下产生区域选择性和立体选择性化合物,这些条件可以标记为“天然”。

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