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Gold Nanostar Colorimetric Detection of Fructosyl Valine as a Potential Future Point of Care Biosensor Candidate for Glycated Haemoglobin Detection

机译:金纳米星比色法检测果糖基缬氨酸作为糖化血红蛋白检测的潜在的未来护理生物传感器候选点

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摘要

Diabetes Mellitus is a growing global concern. The current methods used to detect glycated haemoglobin are precise, however, utilise expensive equipment, reagents and consumables. These are luxuries which rural communities cannot access. The nanotechnology methods which have been developed for glycated haemoglobin detection are predominantly electrochemically based, have complicated lengthy fabrication processes and utilise toxic chemicals. Here a fructosyl amino acid oxidase gold nanostar biosensor has been developed as a potential future point of care biosensor candidate for glycated haemoglobin detection. The workup done on this biosensor showed that it was able to give a spectrophotometric readout and colorimetric result with naked eye detection in blank serum spiked with fructosyl valine.
机译:糖尿病是全球关注的焦点。用于检测糖化血红蛋白的当前方法是精确的,但是使用昂贵的设备,试剂和消耗品。这些是农村社区无法获得的奢侈品。已经开发出用于糖化血红蛋白检测的纳米技术方法主要是基于电化学的,具有复杂的冗长的制造过程并利用有毒化学物质。在这里,果糖基氨基酸氧化酶金纳米星生物传感器已被开发为糖化血红蛋白检测的潜在未来护理生物传感器候选者。在该生物传感器上进行的后处理表明,通过肉眼检测在果糖基缬氨酸加标的空白血清中,它能够通过分光光度法读数和比色结果。

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