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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro In Vivo and Clinical Studies
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Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro In Vivo and Clinical Studies

机译：槲皮素对高血压的药理作用及其在妊高征中的潜在应用：体外体内和临床研究综述

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Since improving maternal and child health is a public health priority worldwide, the main aim of treatment of hypertension in pregnant women is to prevent complications during pregnancy, labor, and postpartum. In consequence, much attention is paid to the use of antihypertensive drugs that can be used safely during pregnancy. Several side effects of methyldopa, which is currently the most commonly used antihypertensive drug in pregnant women, mean that the search for an effective and safe alternative still continues. Flavonoid compounds present in medicinal plants, vegetables, and fruits may be a promising source of new drugs. In this aspect, quercetin, a well-known flavonoid due to its antihypertensive action, may be considered a prototype for safe antihypertensive drugs. This review focuses on the selective activity of quercetin. Based on recent studies, a few problems were discussed, including (1) pathology of pregnancy-induced hypertension; (2) search for new pharmacological treatments of pregnancy-induced hypertension; (3) issues with the use of herbal extracts during pregnancy; (4) flavonoids as natural active chemical compounds; (5) quercetin: its action during pregnancy, in vitro and in vivo pharmacological activities, clinical trials, and meta-analysis; (6) quercetin intake during pregnancy; (7) other natural compounds tested during pregnancy; (8) potential problems with the use of quercetin; (9) safety profile of quercetin. Various studies have shown a beneficial effect of quercetin on vascular endothelial function and its antioxidative and anti-inflammatory activity on cellular and tissue level. It is known that in animal models quercetin affects positively the development of embryo, fetus, and placenta. Because this flavonoid did not have teratogenic and abortive effect, it is generally recognized as safe. For this reason it should be appreciated and studied in the aspect of its potential use in the prevention and treatment of pregnancy-induced hypertension among women in this risk group.
机译：由于改善母婴健康是全球范围内的公共卫生重点，因此，治疗孕妇高血压的主要目的是防止怀孕，分娩和产后并发症。因此，人们非常重视在妊娠期间可以安全使用的降压药的使用。甲基多巴（目前是孕妇中最常用的降压药）有几种副作用，这意味着仍在继续寻找有效和安全的替代品。药用植物，蔬菜和水果中存在的类黄酮化合物可能是新药的有希望的来源。在这方面，槲皮素是一种众所周知的类黄酮，因其具有降压作用，可以被认为是安全降压药的原型。这篇综述着重于槲皮素的选择性活性。根据最近的研究，讨论了一些问题，包括：（1）妊娠高血压综合征的病理学； （2）寻找妊娠高血压综合征的新药理疗法； （3）怀孕期间使用草药提取物的问题； （4）类黄酮为天然活性化合物； （5）槲皮素：其在妊娠期的作用，体内外药理活性，临床试验和荟萃分析； （6）孕期槲皮素的摄入量； （7）怀孕期间测试的其他天然化合物； （8）使用槲皮素的潜在问题； （9）槲皮素的安全性。各种研究表明槲皮素对血管内皮功能及其在细胞和组织水平的抗氧化和抗炎活性具有有益作用。众所周知，在动物模型中，槲皮素对胚胎，胎儿和胎盘的发育有积极影响。由于该类黄酮不具有致畸和流产作用，因此通常被认为是安全的。因此，在该风险人群中其在预防和治疗妊娠高血压引起的潜在用途方面应受到赞赏和研究。

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