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首页> 美国卫生研究院文献>Frontiers in Psychiatry >Nonpharmacological Interventions for the Treatment of Cardiometabolic Risk Factors in People With Schizophrenia—A Systematic Review
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Nonpharmacological Interventions for the Treatment of Cardiometabolic Risk Factors in People With Schizophrenia—A Systematic Review

机译：非药物干预治疗精神分裂症患者心脏代谢危险因素的系统评价

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>Background: People suffering from schizophrenia are notably vulnerable to cardiometabolic risk factors (CMRF), such as obesity, high blood pressure, hyperglycemia and insulin resistance, high serum triglycerides, and low serum high-density lipoprotein (HDL), which are related to increased mortality and decreased quality of life. The increased risk of “metabolic syndrome” (MS) is related to low physical activity, an unhealthy diet, and side effects of antipsychotic drugs. Nonpharmacological interventions seem to be important in the prevention and therapy of MS. >Aim: This paper provides an overview of published studies and a critical analysis of pilot programs involving nonpharmacological measures aimed at prevention and treatment of CMRF in patients with schizophrenia. >Material and Method: We searched the PubMed, PsycARTICLES, and Cochrane Library databases to identify clinical trials. We included full-text studies that met the following criteria: age > 18 years, a diagnosis of schizophrenia or schizoaffective disorder, and monitored parameters associated with MS. >Results: All 1,555 references were evaluated for inclusion in the review, and 20 met the inclusion criteria. Nonpharmacological interventions led to improvement in physical health and showed a promising potential for implementation in treatment programs dedicated to this particular group of patients. However, a critical analysis revealed limitations, which have implications for the direction of future research. >Conclusions: Patients suffering from schizophrenia can benefit from nonpharmacological interventions aimed at counteracting CMRF, improving either metabolic parameters, cardiovascular fitness, or their health perception. Notwithstanding, to achieve long-term effects, future studies should comprise appropriate follow-up procedures.
机译：>背景：精神分裂症患者特别容易患肥胖，高血压，高血糖和胰岛素抵抗，血浆甘油三酯高和血清高密度脂蛋白（HDL）低等心脏代谢危险因素（CMRF） ），这与死亡率增加和生活质量下降有关。 “代谢综合征”（MS）的风险增加与体育活动量低，饮食不健康以及抗精神病药的副作用有关。非药物干预似乎对MS的预防和治疗很重要。 >目标：本文对已发表的研究进行了概述，并对涉及旨在预防和治疗精神分裂症患者的CMRF的非药理学措施的试验计划进行了批判性分析。 >材料和方法：我们搜索了PubMed，PsycARTICLES和Cochrane库数据库，以鉴定临床试验。我们纳入了符合以下条件的全文研究：年龄> 18岁，诊断为精神分裂症或精神分裂症，并监测与MS相关的参数。 >结果：对所有1,555篇参考文献进行了评估，以纳入评价，其中20篇符合纳入标准。非药物干预措施可改善身体健康状况，并显示出在针对该特定患者组的治疗计划中实施的潜力。但是，批判性分析揭示了局限性，这对未来研究的方向具有影响。 >结论：患有精神分裂症的患者可以受益于旨在抵消CMRF，改善代谢参数，心血管适应性或健康意识的非药物干预措施。尽管如此，为了取得长期效果，未来的研究应包括适当的随访程序。

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