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Interleukin-22: immunobiology and pathology

机译:白介素22:免疫生物学与病理学

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摘要

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T-helper (Th)-17 cells, γδ T cells, NKT cells and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has rapidly evolved since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues including the intestines, lung, liver, kidney, thymus, pancreas and skin. IL-22 primarily targets non-hematopoietic epithelial and stromal cells where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we will assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.
机译:白介素-22(IL-22)是最近描述的IL-10家族细胞因子,由T辅助(Th)-17细胞,γδT细胞,NKT细胞和新近描述的先天淋巴样细胞(ILC)产生。自2000年被发现以来,IL-22生物学的知识迅速发展,并且IL-22在肠,肺,肝,肾,胸腺,胰腺和皮肤等众多组织中的作用已得到确认。 IL-22主要靶向非造血上皮和基质细胞,在这些细胞中它可以促进增殖并在组织再生中起作用。另外,IL-22调节屏障表面的宿主防御。但是,IL-22也与涉及炎症性组织病理的几种疾病有关。在这篇综述中,我们将评估目前对该细胞因子的了解,包括其对上皮细胞功能的生理和病理影响。

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