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Interleukin-22: Immunobiology and Pathology

机译:白细胞介素-22:免疫学和病理学

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摘要

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by helper (Th) 17 cells, gamma delta cells, NKT cells, and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has evolved rapidly since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues, including the intestines, lung, liver, kidney, thymus, pancreas. and skin. IL-22 primarily targets nonhematopoietic epithelial and stromal cells, where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.
机译:白细胞介素-22(IL-22)是最近描述的IL-10家族细胞因子,其通过辅助(TH)17细胞,γδ细胞,NKT细胞和新描述的先天淋巴细胞(ILC)产生。 自2000年发现以来,IL-22生物学的知识已经迅速发展,并且在许多组织中发现了IL-22的作用,包括肠,肺,肝,肾,胸腺,胰腺。 和皮肤。 IL-22主要针对非肝细胞上皮和基质细胞,可以促进增殖并在组织再生中发挥作用。 此外,IL-22在屏障表面调节主体防御。 然而,IL-22也与涉及炎症组织病理学的几种病症有关。 在本综述中,我们评估目前对这种细胞因子的理解,包括其对上皮细胞功能的生理和病理作用。

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