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首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Comparison of Capsular Genes of Streptococcus pneumoniae Serotype 6A 6B 6C and 6D Isolates
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Comparison of Capsular Genes of Streptococcus pneumoniae Serotype 6A 6B 6C and 6D Isolates

机译：肺炎链球菌血清型6A6B6C和6D分离株的荚膜基因的比较

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Recently, Streptococcus pneumoniae serotypes 6C and 6D have been identified. It is thought that they emerged by the replacement of wciNβ in the capsular loci of serotypes 6A and 6B, respectively. However, their evolution has not been unveiled yet. To investigate the evolution of four serotypes of S. pneumoniae serogroup 6, four genes of the capsular polysaccharide synthesis (cps) locus, wchA, wciN, wciO, and wciP, of isolates of S. pneumoniae serotypes 6A, 6B, 6C, and 6D were sequenced. Multilocus sequence typing (MLST) was performed to investigate their genetic backgrounds. The wchA gene of serotype 6C and 6D isolates was distinct from that of serotype 6A and 6B isolates, which may suggest cotransfer of wchA with wciNβ. Otherwise, serotypes 6C and 6D displayed different genetic backgrounds from serotypes 6A and 6B, which was suggested by MLST analysis. In addition, serotype 6C isolates showed distinct wciP polymorphisms from other serotypes, which also indicated that serotype 6C had not recently originated from serotype 6A. Although serotype 6D shared the same amino acid polymorphisms of wciO with serotype 6B, wciP of serotype 6D differed from that of serotype 6B. The data indicate the implausibility of the scenario of a recent emergence of the cps locus of serotype 6D by genetic recombination between serotypes 6B and 6C. In addition, five serotype 6A and 6B isolates (6X group) displayed cps loci distinct from those of other isolates. The cps locus homogeneity and similar sequence types in MLST analysis suggest that most of the 6X group of isolates originated from the same ancestor and that the entire cps locus might have recently been transferred from an unknown origin. Serotype 6B isolates showed two or more cps locus subtypes, indicating a recombination-mediated mosaic structure of the cps locus of serotype 6B. The collective data favor the emergence of cps loci of serotypes 6A, 6B, 6C, and 6D by complicated recombination.
机译：最近，已经鉴定出肺炎链球菌血清型6C和6D。认为它们是通过在血清型6A和6B的荚膜基因座中分别替换wciNβ而出现的。但是，它们的演变尚未公开。为了研究肺炎链球菌血清群6的四种血清型的进化，肺炎链球菌血清型6A，6B，6C和6D分离株的荚膜多糖合成（cps）基因座，wchA，wciN，wciO和wciP的四个基因被排序。进行多基因座序列分型（MLST）以研究其遗传背景。血清型6C和6D分离株的wchA基因不同于血清型6A和6B分离株的wchA基因，这可能暗示了wchA与wciNβ的共转移。否则，血清型6C和6D显示出与血清型6A和6B不同的遗传背景，这是由MLST分析提示的。此外，血清型6C分离株显示出与其他血清型截然不同的wciP多态性，这也表明血清型6C并非最近起源于血清型6A。尽管血清型6D具有与血清型6B相同的wciO氨基酸多态性，但血清型6D的wciP与血清型6B有所不同。数据表明通过血清型6B和6C之间的基因重组，近期出现血清型6D的cps基因座的场景是不可能的。另外，五个血清型6A和6B分离株（6X组）显示的 cps 位点与其他分离株不同。 MLST分析中的 cps 基因座同源性和相似的序列类型表明，大多数6X分离株群均来自同一祖先，并且整个 cps 基因座可能最近已被转移。来自未知的来源。血清型6B分离株显示两个或多个 cps 位点亚型，表明重组介导的血清型6B cps 位点的镶嵌结构。收集的数据有助于通过复杂的重组产生血清型6A，6B，6C和6D的 cps 基因座。

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