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首页> 美国卫生研究院文献>PLoS Clinical Trials >Acute Post-Exercise Myofibrillar Protein Synthesis Is Not Correlated with Resistance Training-Induced Muscle Hypertrophy in Young Men
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Acute Post-Exercise Myofibrillar Protein Synthesis Is Not Correlated with Resistance Training-Induced Muscle Hypertrophy in Young Men

机译：急性运动后肌原纤维蛋白合成与年轻人中抵抗训练所致的肌肉肥大无关

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Muscle hypertrophy following resistance training (RT) involves activation of myofibrillar protein synthesis (MPS) to expand the myofibrillar protein pool. The degree of hypertrophy following RT is, however, highly variable and thus we sought to determine the relationship between the acute activation of MPS and RT-induced hypertrophy. We measured MPS and signalling protein activation after the first session of resistance exercise (RE) in untrained men (n = 23) and then examined the relation between MPS with magnetic resonance image determined hypertrophy. To measure MPS, young men (24±1 yr; body mass index  = 26.4±0.9 kg•m2) underwent a primed constant infusion of L-[ring-13C6] phenylalanine to measure MPS at rest, and acutely following their first bout of RE prior to 16 wk of RT. Rates of MPS were increased 235±38% (P<0.001) above rest 60–180 min post-exercise and 184±28% (P = 0.037) 180–360 min post exercise. Quadriceps volume increased 7.9±1.6% (−1.9–24.7%) (P<0.001) after training. There was no correlation between changes in quadriceps muscle volume and acute rates of MPS measured over 1–3 h (r = 0.02), 3–6 h (r = 0.16) or the aggregate 1–6 h post-exercise period (r = 0.10). Hypertrophy after chronic RT was correlated (r = 0.42, P = 0.05) with phosphorylation of 4E-BP1Thr37/46 at 1 hour post RE. We conclude that acute measures of MPS following an initial exposure to RE in novices are not correlated with muscle hypertrophy following chronic RT.
机译：抵抗训练（RT）后的肌肉肥大涉及肌原纤维蛋白合成（MPS）的激活，以扩大肌原纤维蛋白库。然而，RT后的肥大程度是高度可变的，因此我们试图确定MPS的急性激活与RT诱发的肥大之间的关系。我们在未经训练的男性（n = 23）中进行了第一次抵抗运动（RE）后，测量了MPS和信号蛋白的活化，然后检查了MPS与磁共振图像确定的肥大之间的关系。为了测量MPS，年轻人（24±1岁；体重指数= 26.4±0.9 kg•m 2 ）进行了恒定的L- [ring- 13 灌注[C6]苯丙氨酸可在静止状态下以及在RT进行第16周之前第一次进行RE剧烈运动后测量MPS。运动后60-180分钟，MPS发生率比休息后增加235±38％（P <0.001），运动后180-360分钟则增加184±28％（P = 0.037）。训练后，股四头肌体积增加7.9±1.6％（−1.9–24.7％）（P <0.001）。股四头肌肌肉的变化与在1–3 h（r = 0.02），3–6 h（r = 0.16）或运动后1–6 h总计（r = 0.10）。在RE后1小时，慢性RT后的肥大与rE = 0.42，P = 0.05有关，与4E-BP1 Thr37 / 46 的磷酸化有关。我们得出的结论是，新手初次接触RE后MPS的急性措施与慢性RT后的肌肉肥大无关。

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