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首页> 外文期刊>AGE >Hormonal determinants and effect of ER22/23EK glucocorticoid receptor gene polymorphism on health status deterioration in the participants of the Mataró Ageing Study
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Hormonal determinants and effect of ER22/23EK glucocorticoid receptor gene polymorphism on health status deterioration in the participants of the Mataró Ageing Study

机译：Mataró衰老研究参与者的激素决定因素和ER22 / 23EK糖皮质激素受体基因多态性对健康状况恶化的影响

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The purpose of this study is to assess the potential relationships of circulating IGF-I, adrenal and gonadal steroids, and polymorphism ER22/23EK of the glucocorticoid receptor (GC-R) gene with nutritional, functional and cognitive deterioration in a group of elderly people living independently. This is a population-based prospective study with 313 individuals (160 women and 153 men, 76.7 ± 7 years) who participated. A physical exam, evaluation of functional capacity (Barthel scale), cognitive function (mini-mental state examination-MMSE), geriatric depression scale (GDS), mininutritional assessment (MNA-SF) and cardiometabolic status were performed at basal time point and at 2 years of follow-up. Biological measurements included cortisol, dehydroepiandrosterone (DHEA), DHEA sulphate, testosterone, estradiol, IGF-I and polymorphism ER22/23EK of the GC-R gene. Estradiol was associated with MNA-SF decrease over time (p < 0.01, adjusted for age and gender, beta = −0.17, p = 0.03). Weight loss was related to testosterone in men (8.6 vs 12.1 pg/ml in no losers; p = 0.03), and in women with GDS (13.0% with depression vs 3.3% with no depression; p = 0.05) and MMSE (22.2% with cognitive deterioration vs 4.8% with no cognitive deterioration; p = 0.049). Barthel decrease was associated with testosterone (p = 0.02, after adjusting for age and gender, beta = −0.520, p < 0.001), and SHBG (p < 0.01, adjusted for age and gender, beta = 0.18, p < 0.01). DHEA was associated with deterioration in the MMSE (p = 0.01, after adjusting for age, gender, GDS scale and academic status, beta = −0.26, p = 0.01). Frailty development was related only in men with testosterone levels at the beginning of the study (p = 0.017). ER22/23EK was found in 3% of the subjects and carriers had a lower prevalence of hypertension. Adrenal and gonadal steroids are associated to impairment of the ageing health condition in elderly individuals living independently in Spain. ER22/23EK polymorphism of the GC-R gene has a low prevalence in our population.
机译：这项研究的目的是评估一群老年人中循环中的IGF-I，肾上腺和性腺类固醇以及糖皮质激素受体（GC-R）基因多态性ER22 / 23EK与营养，功能和认知能力下降的潜在关系。独立生活。这是一项基于人群的前瞻性研究，共有313名个体（160名女性和153名男性，76.7±7岁）参加。在基础时间点和基础时间进行体格检查，功能能力评估（Barthel量表），认知功能评估（小精神状态检查-MMSE），老年抑郁量表（GDS），微量营养评估（MNA-SF）和心脏代谢状态2年的随访。生物学测量包括皮质醇，脱氢表雄酮（DHEA），硫酸DHEA，睾丸激素，雌二醇，IGF-1和GC-R基因的ER22 / 23EK多态性。雌二醇与MNA-SF随时间下降相关（p <0.01，根据年龄和性别调整，β= -0.17，p = 0.03）。体重减轻与男性睾丸激素有关（无输精者分别为8.6 vs 12.1 pg / ml； p = 0.03），以及患有GDS的女性（抑郁症为13.0％，无抑郁症为3.3％； p = 0.05）和MMSE（22.2％）有认知能力恶化的患者为4.8％，无认知能力恶化的患者； p = 0.049）。 Barthel的降低与睾丸激素有关（在校正了年龄和性别后，p = 0.02，β= −0.520，p <0.001）和SHBG（在校正了年龄和性别后，p <0.01，β= 0.18，p <0.01）。 DHEA与MMSE恶化相关（在校正了年龄，性别，GDS量表和学业状况后，p = 0.01，β= -0.26，p = 0.01）。在研究开始时，脆弱发展仅与睾丸激素水平相关（p = 0.017）。在3％的受试者中发现ER22 / 23EK，携带者的高血压患病率较低。在西班牙独立生活的老年人中，肾上腺和性腺类固醇与衰老的健康状况有关。 GC-R基因的ER22 / 23EK多态性在我国人群中患病率较低。

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