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首页> 外文期刊>Applied Surface Science >Surface zwitterionization: Effective method for preventing oral bacterial biofilm formation on hydroxyapatite surfaces
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Surface zwitterionization: Effective method for preventing oral bacterial biofilm formation on hydroxyapatite surfaces

机译：表面两性离子化：防止口腔细菌在羟基磷灰石表面形成生物膜的有效方法

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摘要

In this study, we conducted surface zwitterionization of hydroxyapatite (HA) surfaces by immersing them in the zwitterionic polymer solutions to provide anti-bacterial properties to the HA surface. Three different monomers containing various zwitterionic groups, i.e., phosphorylcholine (PC), sulfobetaine (SB), and carboxybetaine (CB), were copolymerized with the methacrylic monomer containing a Ca2+-binding moiety, using the free radical polymerization method. As a control, functionalization of the copolymer containing the Ca2+-binding moiety was synthesized using a hydroxy group. The stable immobilization of the zwitterionic functional groups was confirmed by water contact angle analysis and X-ray photoelectron spectroscopy (XPS) measurement conducted after the sonication process. The zwitterionized HA surface showed significantly decreased protein adsorption, whereas the hydroxyl group-coated HA surface showed limited efficacy. The anti-bacterial adhesion property was confirmed by conducting Streptococcus mutans (S. mutans) adhesion tests for 6 h and 24 h. When furanone C-30, a representative anti-quorum sensing molecule for S. mutans, was used, only a small amount of bacteria adhered after 6 h and the population did not increase after 24 h. In contrast, zwitterionized HA surfaces showed almost no bacterial adhesion after 6 h and the effect was retained for 24 h, resulting in the lowest level of oral bacterial adhesion. These results confirm that surface zwitterionization is a promising method to effectively prevent oral bacterial adhesion on HA-based materials. (C) 2017 Elsevier B.V. All rights reserved.
机译：在这项研究中，我们通过将羟基磷灰石（HA）表面浸入两性离子聚合物溶液中进行表面两性离子化处理，从而为HA表面提供抗菌性能。使用自由基聚合方法，将含有各种两性离子基团的三种不同单体，即磷酰胆碱（PC），磺基甜菜碱（SB）和羧基甜菜碱（CB）与含有Ca 2+结合部分的甲基丙烯酸单体共聚。作为对照，使用羟基合成了包含Ca 2+结合部分的共聚物的官能化。通过在超声处理之后进行的水接触角分析和X射线光电子能谱（XPS）测量，证实了两性离子官能团的稳定固定。两性离子化的HA表面显示出显着降低的蛋白质吸附，而羟基包覆的HA表面显示出有限的功效。通过进行变形链球菌（变形链球菌）粘附测试6小时和24小时，可以确认抗菌粘附特性。当使用呋喃酮C-30（变形链球菌的代表性抗群体感应分子）时，在6小时后只有少量细菌粘附，而在24小时后种群并未增加。相比之下，两性离子化的HA表面在6 h后几乎没有细菌粘附，并且效果持续了24 h，导致最低水平的口腔细菌粘附。这些结果证实表面两性离子化是有效防止口腔细菌粘附在基于HA的材料上的一种有前途的方法。 （C）2017 Elsevier B.V.保留所有权利。

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  • 来源
    《Applied Surface Science》 |2018年第ptaa期|517-524|共8页
  • 作者

    Lee Myoungjin; Kim Heejin; Seo Jiae; Kang Minji; Kang Sunah; Jang Joomyung; Lee Yan; Seo Ji-Hun;

  • 作者单位

    Korea Univ, Dept Mat Sci & Engn, 145 Anam Ro, Seoul 02841, South Korea;

    Seoul Natl Univ, Dept Chem, Coll Nat Sci, 1 Gwanak Ro, Seoul 08826, South Korea;

    Korea Univ, Dept Mat Sci & Engn, 145 Anam Ro, Seoul 02841, South Korea;

    Seoul Natl Univ, Dept Chem, Coll Nat Sci, 1 Gwanak Ro, Seoul 08826, South Korea;

    Seoul Natl Univ, Dept Chem, Coll Nat Sci, 1 Gwanak Ro, Seoul 08826, South Korea;

    Seoul Natl Univ, Dept Chem, Coll Nat Sci, 1 Gwanak Ro, Seoul 08826, South Korea;

    Seoul Natl Univ, Dept Chem, Coll Nat Sci, 1 Gwanak Ro, Seoul 08826, South Korea;

    Korea Univ, Dept Mat Sci & Engn, 145 Anam Ro, Seoul 02841, South Korea;

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  • 正文语种 eng
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  • 关键词

    Hydroxyapatite; Anti-bacterial adhesion; Anti-biofouling; Zwitterion; Anti-quorum sensing;

    机译：羟基磷灰石;抗菌附着力;抗生物结垢;两性离子;抗群体感应;

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