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首页> 外文期刊>Biomarkers >Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population
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Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population

机译：CCND1的遗传变异：与HPV介导的宫颈癌在印度人口中的关联。

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摘要

The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.51-4.09; p = 0.0004) compared with GG+GA genotypes. For the 1722 locus, the frequency of the polymorphic 'C allele was strongly associated with a reduced risk of cervical cancer (p = 0.019; OR 0.71; 95% CI 0.54-0.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.
机译：研究了CCND1的单核苷酸多态性（SNPs）（G870A和G1722C）与子宫颈癌易感性的潜在关联。该研究包括200例宫颈癌病例以及相同数量的健康对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析和直接测序进行基因分型。我们发现，与GG + GA基因型相比，携带870AA基因型的女性患子宫颈癌的风险增加了2.49倍（优势比（OR）2.49； 95％置信区间（CI）1.51-4.09； p = 0.0004）。 。对于1722个基因座，多态性'C等位基因的频率与降低子宫颈癌的风险密切相关（p = 0.019; OR 0.71; 95％CI 0.54-0.94）。我们的数据表明CCND1 G870A多态性可能是宫颈癌发展的危险因素。 G1722C多态性可能在印度女性中对人类乳头瘤病毒相关宫颈癌的发展起保护作用。

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  • 来源
    《Biomarkers》 |2009年第4期|219-225|共7页
  • 作者

    Nisha Thakur; Showket Hussain; Indu Kohaar; Rubina Tabassum; Vilas Nasare; Pratibha Tiwari; Swaraj Batra; Suresh Bhambhani; Bhudev C. Das; Seemi Farhat Basir; Dwaipayan Bharadwaj; Mausumi Bharadwaj;

  • 作者单位

    Divisions of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), Noida, India;

    Molecular Oncology, Institute of Cytology & Preventive Oncology (ICMR), Noida, India;

    Divisions of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), Noida, India;

    Functional Genomics Unit, Institute of Genomics & Integrative Biology (CSIR), Delhi, India;

    Divisions of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), Noida, India;

    Divisions of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), Noida, India;

    Department of Obstetrics & Gynaecology, LNJP Hospital, New Delhi, India;

    Cytopathology, Institute of Cytology & Preventive Oncology (ICMR), Noida, India;

    Molecular Oncology, Institute of Cytology & Preventive Oncology (ICMR), Noida, India;

    Department of Biosciences, Jamia Millia Islamia, New Delhi, India;

    Functional Genomics Unit, Institute of Genomics & Integrative Biology (CSIR), Delhi, India;

    Division of Molecular Genetics & Biochemistry, Institute of Cytology & Preventive Oncology (ICMR), 1-7, Sector 39, Noida 201301, India;

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  • 正文语种 eng
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  • 关键词

    cydin D1; cervical cancer; human papillomavirus; single nucleotide polymorphism; G870A; G1722C;

    机译：cydin D1;宫颈癌;人乳头状瘤病毒;单核苷酸多态性G870A;G1722C;

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