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首页> 外文期刊>Bioprocess and Biosystems Engineering >2-Pyrrolidone synthesis from gamma-aminobutyric acid produced by Lactobacillus brevis under solid-state fermentation utilizing toxic deoiled cottonseed cake
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2-Pyrrolidone synthesis from gamma-aminobutyric acid produced by Lactobacillus brevis under solid-state fermentation utilizing toxic deoiled cottonseed cake

机译：利用有毒的脱油棉饼在固态发酵下由短乳杆菌生产的γ-氨基丁酸合成2-吡咯烷酮

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摘要

There is an increasing demand of gamma-aminobutyric acid (GABA) as drug and food additive, as well as feedstock to produce 2-pyrrolidone, a precursor for the synthesis of nylon 4. 2-Pyrrolidone is a petrochemical and depleting reserve which raises concern for its bio-based production. The study herein describes bio-based economical GABA production from Lactobacillus brevis by solid-state fermentation (SSF) using toxic deoiled cottonseed cake (CSC) as substrate. In general, the use of cottonseed cake remains restricted due to the presence of toxic gossypols. Thus, simultaneous detoxification observed during fermentation also widens the scope of utilization of this residual seedcake for feed use vis-a-vis production of other value added chemicals. The SSF conditions were optimized for maximum GABA production, viz., 19.7 mg/g, CSC of GABA was obtained at 6th day of fermentation with 70 % degradation of gossypols simultaneously. The potential of this bio-based GABA as a platform chemical is demonstrated in the synthesis of 2-pyrrolidone. Thus, a simple and cost-effective strategy for utilizing toxic biomass has been developed as an alternate to chemical synthetic route.
机译：对用作药物和食品添加剂的γ-氨基丁酸（GABA）以及生产2-吡咯烷酮（合成尼龙4的前体）的原料的需求不断增长。2-吡咯烷酮是一种石油化学消耗品，备受关注用于生物生产。本文的研究描述了使用有毒的脱油棉籽饼（CSC）作为底物，通过固态发酵（SSF）从短乳杆菌生产基于生物的经济型GABA。通常，由于有毒棉酚的存在，棉籽饼的使用仍然受到限制。因此，在发酵过程中观察到的同时解毒也相对于生产其他增值化学品扩大了该残留种子饼作为饲料用途的利用范围。对SSF条件进行了优化，以最大程度地生产GABA，即19.7 mg / g，在发酵的第6天获得了CSC的GABA，同时棉酚的降解率为70％。这种生物基GABA作为平台化学品的潜力在2-吡咯烷酮的合成中得到了证明。因此，已经开发出一种利用有毒生物质的简单且具有成本效益的策略，作为化学合成路线的替代方案。

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