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首页> 外文期刊>Brain Tumor Pathology >Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas
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Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas

机译：Nestin在脑肿瘤中的表达：其在病理诊断中的作用以及与高级神经胶质瘤的预后相关

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One of the type VI intermediate filament proteins, nestin, is expressed in neuroepithelial stem cells during neural embryogenesis. Nestin is also expressed in a variety of neoplasms. Its expression in brain tumors has not been thoroughly studied. The objectives of this study were to survey nestin expression in different types of brain tumor, and to evaluate nestin as a marker for diagnosis and prognosis. We used tissue microarrays of 257 brain tumors for an immunohistochemical overview of nestin expression: nestin was frequently expressed in gliomas and schwannomas. Most of the gliomas that expressed high levels of nestin were high-grade gliomas (anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas, and glioblastomas). We then focused on high-grade gliomas and performed immunohistochemistry again, using whole-mount slides. As a result, we found (1) significantly different nestin expression between glioblastomas and other high-grade gliomas, and (2) worse overall survival for high-grade gliomas with high nestin expression. Our results suggest that: (1) nestin is a useful marker for diagnosis of high-grade gliomas, (2) nestin is helpful in diagnosis of schwannomas, and (3) nestin expression is related to poor prognosis in high-grade gliomas.
机译：VI型中间丝蛋白之一Nestin在神经胚发生过程中在神经上皮干细胞中表达。巢蛋白还在多种肿瘤中表达。其在脑肿瘤中的表达尚未得到彻底研究。这项研究的目的是调查巢蛋白在不同类型的脑肿瘤中的表达，并评估巢蛋白作为诊断和预后的标志物。我们使用257个脑肿瘤的组织芯片进行了巢蛋白表达的免疫组化综述：巢蛋白经常在神经胶质瘤和神经鞘瘤中表达。大部分表达巢蛋白的神经胶质瘤是高级别神经胶质瘤（间变性星形细胞瘤，间变性少突胶质细胞瘤，间变性少星形细胞瘤和胶质母细胞瘤）。然后，我们将重点放在高级别神经胶质瘤上，并使用全载玻片再次进行免疫组织化学。结果，我们发现（1）胶质母细胞瘤和其他高级神经胶质瘤之间的巢蛋白表达明显不同，（2）巢蛋白表达高的高级神经胶质瘤的总生存期较差。我们的结果表明：（1）nestin是诊断高级神经胶质瘤的有用标志物；（2）nestin对神经鞘瘤的诊断有帮助；（3）nestin表达与高级神经胶质瘤的不良预后有关。

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