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首页> 外文期刊>Breast Cancer >Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report
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Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report

机译：曲妥珠单抗联合卡培他滨成功治疗乳腺癌的软脑膜转移：1例

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摘要

We report a case of metastatic breast cancer with leptomeninges and multiple bone metastases that showed an excellent response to the combination of trastuzumab and capecitabine; therapeutic effect was evaluated by MRI at follow-up. A 44-year-old woman underwent modified radical mastectomy in February 1997. In April 2003, a tumor at the right basis cerebri and multiple bone metastases were noted, and in October 2003, she underwent enucleation of the tumor. Histopathologically, the tumor was consistent with a basal skull metastasis from breast cancer. In March 2004, the patient began to experience pain, weakness, and paresthesia of both legs. She was diagnosed, with leptomeningeal metastasis (LM) from breast cancer using MRI. In December 2005, the combination of trastuzumab and capecitabine administered as sixth-line treatment was very effective for LM. Although it is generally very difficult to diagnose LM and assess the therapeutic effect with MRI, in this case, it was possible. To our knowledge, there has been no report in the literature describing the combination of trastuzumab and capecitabine for LM from breast cancer. Although the mechanism underlying the efficacy of this combination is still unknown, the treatment would be worth trying because of its few side effects in extensively treated patients with LM from breast cancer. To confirm the antitumor efficacy of trastuzumab and capecitabine, however, further investigations are required.
机译：我们报告了一例转移性乳腺癌，伴发轻薄和多发性骨转移，对曲妥珠单抗和卡培他滨联合治疗表现出极好的反应。随访时通过MRI评估治疗效果。一名44岁的妇女于1997年2月进行了改良的根治性乳房切除术。2003年4月，发现右脑小脑肿瘤和多处骨转移，2003年10月，她进行了肿瘤摘除术。在组织病理学上，该肿瘤与乳腺癌的基础颅骨转移一致。 2004年3月，患者开始出现双腿疼痛，无力和感觉异常。使用MRI诊断出她患有乳腺癌的软脑膜转移（LM）。 2005年12月，将曲妥珠单抗和卡培他滨联合作为六线治疗对LM非常有效。尽管通常很难诊断LM并用MRI评估治疗效果，但在这种情况下还是有可能的。据我们所知，目前尚无文献报道曲妥珠单抗和卡培他滨联合用于乳腺癌的LM。尽管这种组合的功效的基本机制仍是未知的，但该疗法值得一试，因为它在广泛治疗的患有乳腺癌的LM患者中几乎没有副作用。为了证实曲妥珠单抗和卡培他滨的抗肿瘤功效，还需要进一步的研究。

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  • 来源
    《Breast Cancer》 |2009年第1期|88-92|共5页
  • 作者

    Takashi Shigekawa; Hideki Takeuchi; Misono Misumi; Kazuo Matsuura; Hiroshi Sano; Nobuko Fujiuchi; Katsuhiko Okubo; Akihiko Osaki; Kenjiro Aogi; Toshiaki Saeki;

  • 作者单位

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

    Department of Surgery National Hospital Organization Shikoku Cancer Center 160 Kou Minamiumemoto Matsuyama Ehime 791-0280 Japan;

    Department of Breast Oncology Saitama Medical University International Medical Center 1397-1 Yamane Hidaka Saitama 350-1298 Japan;

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  • 正文语种 eng
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  • 关键词

    Breast cancer; Leptomeningeal metastasis; Trastuzumab; Capecitabine;

    机译：乳腺癌;脑膜转移;曲妥珠单抗;卡培他滨;

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