• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World Journal of Gastroenterology >Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma.
【24h】

Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma.

机译：血浆von Willebrand因子水平可作为转移性结直肠癌患者的预后指标。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: To evaluate the correlations of plasma von Willebrand factor (vWF) level with the distant metastasis and prognosis of patients with colorectal cancer. METHODS: A total of 86 patients with histologically confirmed metastatic colorectal cancers receiving treatment at Taipei Veterans General Hospital were enrolled. All patients had measurable metastatic lesions and life expectancies of more than 3 mo. Plasma vWF levels were measured by immuno-turbidimetric assay and compared with results from 40 non-metastatic colorectal cancer patients and 22 healthy controls. Patients with metastatic colorectal cancer were divided into two groups according to serum vWF levels and the differences between these two groups were analyzed using chi(2) test. Data on age, gender, performance status, location of primary tumor, extent of metastasis, site of metastases, histological differentiation, serum CEA and plasma vWF levels were analyzed to determine association with survival. Survival curves were constructed by Kaplan-Meier product limit method and the data was analyzed using log-rank test on a microcomputer. Multivariate analysis using the Cox's proportional hazards regression model was then performed to determine the independent prognostic indicators among all of the possible variables. RESULTS: Colorectal cancer patients were identified as having significantly higher plasma vWF concentrations than healthy controls (P<0.05). Moreover, higher vWF plasma levels were associated with advanced tumor stage (P<0.05) and the presence of multiple metastases (P = 0.014). Patients with lower vWF plasma levels (<=160%) survived significantly longer than those with a higher plasma vWF level (log-rank test, P = 0.0043). By multivariate analysis, plasma vWF levels (P<0.001), the extent of metastasis (P = 0.012), and the performance status (P = 0.014) were identified as independent prognostic factors. CONCLUSION: Our data indicates that high plasma vWF concentrations correlate with advanced diseases and significantly poor prognosis of patients with metastatic colorectal carcinoma. It may serve as a potential biological marker of disease progression in these patients.
机译：目的：探讨血浆血管性假血友病因子（vWF）水平与大肠癌患者远处转移及预后的关系。方法：纳入台北退伍军人总医院接受治疗的经组织学证实为转移性大肠癌的86例患者。所有患者均具有可测量的转移性病变，预期寿命超过3 mo。通过免疫比浊法测定血浆vWF水平，并将其与40例非转移性结直肠癌患者和22例健康对照的结果进行比较。根据血清vWF水平将转移性大肠癌患者分为两组，并使用chi（2）测试分析两组之间的差异。分析有关年龄，性别，机能状态，原发肿瘤位置，转移程度，转移部位，组织学分化，血清CEA和血浆vWF水平的数据，以确定其与生存率的关系。通过Kaplan-Meier乘积极限法构建存活曲线，并在微型计算机上使用对数秩检验分析数据。然后使用Cox比例风险回归模型进行多变量分析，以确定所有可能变量中的独立预后指标。结果：大肠癌患者的血浆vWF浓度明显高于健康对照组（P <0.05）。此外，较高的vWF血浆水平与晚期肿瘤分期（P <0.05）和多种转移的存在有关（P = 0.014）。血浆vWF水平较低（<= 160％）的患者比血浆vWF水平较高的患者生存时间长得多（对数秩检验，P = 0.0043）。通过多变量分析，血浆vWF水平（P <0.001），转移程度（P = 0.012）和生产状况（P = 0.014）被确定为独立的预后因素。结论：我们的数据表明血浆高vWF浓度与转移性结直肠癌患者的晚期疾病和预后显着差有关。它可以作为这些患者疾病进展的潜在生物学标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号